摘要
目的通过职业流行病学调查和基准剂量(BMD)计算,对低剂量职业性氟化氢接触骨代谢指标进行相关性分析。方法于2021年5月,采用整群抽样方法,选择某公司接触氟化氢作业工人(237人)为接触组,某电子生产企业未接触氟化氢工人(83人)为对照组。测定工人氟化氢接触外剂量值、尿氟浓度、血尿生化指标结果,以血清骨钙素(BGP)、血清碱性磷酸酶(AKP)、尿羟脯氨酸(HYP)作为效应标志物,采用基准剂量计算软件(BMDS 1.3.2)计算各效应标志物对应的尿氟BMD并对数据进行统计学分析。结果接触组工人尿氟浓度与肌酐校正后的尿氟浓度具有相关性(r=0.69,P=0.001);接触组工人氟化氢外剂量值与尿氟值相关性无统计学意义(r=0.03,P=0.132)。接触组和对照组工人尿氟浓度分别为(0.81±0.61)、(0.45±0.14)mg/L,两组差异有统计学意义(t=5.01,P=0.025),以BGP、AKP、HYP为效应指标计算的尿氟BMDL-05分别为1.28、1.47、1.08 mg/L。结论尿氟能够敏感地反映出骨代谢生化指标的效应指标的改变,BGP和HYP可作为职业性氟化氢接触的早期敏感的效应指标。
Objective To analyze correlation of occupational hydrogen fluoride exposure to low doses of bone metabolism index through occupational epidemiological investigation and benchmark dose calculation.Methods In May 2021,using cluster sampling method,237 workers exposed to hydrogen fluoride in a company were selected as the contact group,and 83 workers not exposed to hydrogen fluoride in an electronics production company were selected as the control group.The external exposure dose and urinary fluoride concentration,blood and urine biochemical indicators of the workers was measured.The relationship between external dose and internal dose of hydrogen fluoride was analyzed.The external dose,urinary fluoride was used as exposure biomarkers,while serum osteocalcin(BGP),serum alkaline phosphatase(AKP)and urinary hydroxyproline(HYP)were used as effect biomarkers for bone metabolism of hydrogen fluoride exposure.The benchmark dose calculation software(BMDS1.3.2)was used to calculate benchmark dose(BMD).Results Urine fluoride concentration in the contact group was correlated with creatinine-adjusted urine fluoride concentration(r=0.69,P=0.001).There was no significant correlation between the external dose of hydrogen fluoride and urine fluoride in the contact group(r=0.03,P=0.132).The concentrations of urine fluoride in the contact group and the control group were(0.81±0.61)and(0.45±0.14)mg/L,respectively,and the difference between the two groups was statistically significant(t=5.01,P=0.025).Using BGP,AKP and HYP as effect indexes,the urinary BMDL-05 values were 1.28,1.47 and 1.08 mg/L,respectively.Conclusion Urinary fluoride can sensitively reflect the changes in the effect indexes of biochemical indexes of bone metabolism.BGP and HYP can be used as early sensitive effect indexes of occupational hydrogen fluoride exposure.
作者
郑光
李凤仪
王翔
朱冬青
赵忠林
郭盈
Zheng Guang;Li Fengyi;Wang Xiang;Zhu Dongqing;Zhao Zhonglin;Guo Ying(Occupational Health Guidance Center,Shanghai Institute of Occupational Disease for Chemical Industry,Shanghai 200041,China;Business Department,Hefei Kanghong Occupational Health Medical Examination Center,Hefei 230088,China;Central Laboratory,Shanghai Institute of Occupational Disease for Chemical Industry,Shanghai 200041,China;Health Care Center,Shanghai Institute of Occupational Disease for Chemical Industry,Shanghai 200041,China)
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
北大核心
2023年第3期198-203,共6页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
上海市第五轮公共卫生体系建设三年行动计划(2020-2022)
环境与职业卫生学重点学科建设项目(GWV-10.1-XK12)
上海市卫生健康地方标准预研制项目(2021WB26)。
关键词
职业暴露
尿氟
氟化氢
骨代谢
基准剂量
低剂量
生化指标
Occupational exposure
Urinary fluoride
Hydrogen fluoride
Bone metabolism
Benchmark dose
Low doses
Biochemical index
