摘要
目的分析6783例阴虚证处方中地骨皮的用药规律,为地骨皮的临床应用与药理学研究提供理论基础与参考。方法本研究病例由福建中医药大学附属人民医院提供。收集2018年至2020年处方中使用地骨皮的所有病例,剔除与阴虚证完全无关的病例,最终纳入6783例。通过中医传承计算平台,构建地骨皮相关数据库,统计主治证候、主治中医疾病、主治西医疾病频次,分析总体药物使用情况,分析置信度为0.9时,不同支持度下地骨皮治疗阴虚证配伍的核心药材及其组合规律。随后采用基于Apriori关联规则算法进一步挖掘地骨皮高频次应用的证候类型中配伍的核心药材及其组合规律。结果在6783例阴虚证处方中,地骨皮主治的阴虚证高度集中在肝、肾等脏腑的阴虚证;主治中医疾病类型共121种,使用频次≥200的有5种疾病,其中频次最高的3种疾病分别为消渴病、白涩病、瘿病;主治西医疾病741种,2型糖尿病、干眼症、结膜炎位列处方频次前3。地骨皮在阴虚证处方中配伍频次最高的前3味药为白芍、生地黄、黄芪,其核心组合为地骨皮-白芍、地骨皮-生地黄、地骨皮-黄芪。气阴两虚证中,核心配伍药物主要有黄芪、知母、白芍、茯苓、川芎,其配伍组合为地骨皮-黄芪-知母、地骨皮-茯苓、地骨皮-知母、黄芪-知母、地骨皮-白芍、地骨皮-黄芪、地骨皮-川芎,且地骨皮-川芎与黄芪-知母组合在气阴两虚证中具有特殊协同意义。肝阴虚证中,核心配伍药材有3味药,即白芍、玄参、生地黄(支持度高达60%),其配伍组合为地骨皮-白芍-玄参、地骨皮-白芍-生地黄、白芍-玄参、地骨皮-白芍、地骨皮-生地黄、地骨皮-玄参、白芍-生地黄。肾阴虚证中,核心配伍药材有4味药,即白芍、麦冬、生地黄、玄参(支持度高达40%),其核心组合为地骨皮-白芍、地骨皮-生地黄、地骨皮-麦冬、地骨皮-玄参,其
Objective To explore the potential rules of Cortex Lycii in 6783 prescriptions of Yin deficiency syndrome,so as to provide the theoretical basis and reference for clinical application and pharmacological research of Cortex Lycii.Methods The cases involved in this study were provided by Fujian Provincial People's Hospital.A total of 6783 prescriptions of Yin deficiency syndrome containing Cortex Lycii from 2018 to 2020 were collected.and input into the traditional Chinese Medicine(TCM)inheritance calculation platform to establish the database.The frequencies of symptom types,main TCM diseases,and main diseases were counted.The overall drugs,the core medicinal materials and their combination rules in the treatment of Yin deficiency syndrome were statistically analyzed under different support degrees when the confidence was 0.9.Finally,the core medicinal materials and their combination rules of Cortex Lycii in high-frequency applied syndrome types were further statistically analyzed by the Apriori association rule algorithm.Results The Yin deficiency syndrome mainly treated was highly concentrated in the liver and kidney.There were 5 kinds of diseases with frequency≥200,among which the top three with the highest frequencies were Xiaoke disease,white astringent disease,and gall disease.There were 741 kinds of diseases,the top three with the highest frequencies were type 2 diabetes mellitus,xerophthalmia,and conjunctivitis.Baishao,Radix Rehmanniae,and Huangqi were the top three with the highest compatibility frequency in the prescription of Yin deficiency syndrome.Its core combinations were Cortex Lycii-Baishao,Cortex Lycii–Radix Rehmanniae,and Cortex Lycii-Huangqi.The core compatible herbs in the Qi and Yin deficiency syndrome mainly included Huangqi,Zhimu,Baishao,Poria Cocos,and Chuanxiong.The core combinations were Cortex Lycii-Huangqi-Zhimu,Cortex Lycii-Poria Cocos,Cortex Lycii-Zhimu,Huangqi-Zhimu,Cortex Lycii-Baishao,Cortex Lycii-Huangqi,Cortex Lycii-Chuanxiong.Among which,Cortex Lycii–Chuanxiong and Huangq
作者
洪智源
江川
章靓
刘清华
王英豪
黄美霞
Hong Zhiyuan;Jiang Chuan;Zhang Liang;Liu Qinghua;Wang Yinghao;Huang Meixia(College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Pharmaceutical Department,Fujian Provincial People's Hospital,Fuzhou 350004,China)
出处
《国际医药卫生导报》
2023年第7期962-968,共7页
International Medicine and Health Guidance News
基金
福建中医药大学基础类学科科研提升计划项目(XJC2022013)
福建省直属教育和科研专项(X2021004-财务专项)。
关键词
地骨皮
中医传承计算平台
数据挖掘
临床分析
组方规律
Cortex Lycii
TCM heritage computing platform
Data mining
Clinical analysis
Prescription rules
