摘要
目的 探讨丁苯酞联合静脉溶栓治疗急性脑梗死的疗效。方法 选取2019年1月至2021年12月黑龙江省农垦总局总医院第六住院部收治的急性脑梗死患者98例作为研究对象,随机分为对照组和观察组,各49例。对照组采用阿替普酶静脉溶栓治疗,观察组采用丁苯酞联合阿替普酶静脉溶栓治疗。比较两组临床疗效,治疗前后神经功能及血液流变学指标变化。结果 观察组治疗有效率为(91.84%),高于对照组(75.51%)(χ2=4.780,P<0.05)。治疗后,观察组美国国立卫生研究院卒中量表(NIHSS)评分为(10.84±2.41),低于对照组(15.26±3.23)(t=7.677,P<0.05)。治疗后,观察组血液流变学指标全血高切黏度(HSV)、全血低切黏度(LSV)、血浆黏度(PSV)及纤维蛋白原(FIB)水平分别为(3.27±0.60)m Pa·s、(5.09±1.36)m Pa·s、(1.13±0.17)m Pa·s、(3.51±1.58)g/L,均低于对照组(4.02±0.78)m Pa·s、(6.30±1.52)m Pa·s、(1.35±0.26)m Pa·s、(4.34±1.76)g/L(t=5.335、4.153、4.957、2.456,P<0.05)。结论 丁苯酞联合静脉溶栓治疗急性脑梗死临床疗效显著,能有效改善患者神经功能及血液流变学。
Objective To explore the effect of butylphthalide combined with intravenous thrombolytic therapy on acute cerebral infarction.Methods From January 2019 to December 2021,98 patients with acute cerebral infarction admitted to the sixth inpatient department of the General Hospital of Heilongjiang Provincial General Administration of Agricultural Reclamation were selected as the study subjects,and were randomly divided into control group and observation group,with 49 patients in each group.The control group was treated with intravenous thrombolytic therapy with alteplase,while the observation group was treated with intravenous thrombolytic therapy with butylphthalide combined with alteplase.The clinical efficacy,neurological function and hemorheology indexes before and after treatment were compared between the two groups.Results The effective rate of observation group was(91.84%),which was higher than that of control group(75.51%)(x2-=4.780,P<0.05).After treatment,the NIHSS score of the observation group was(10.84±2.41),which was lower than that of the control group(15.26±3.23)(t-7.677,P<0.05).After treatment,the levels of HSV,LSV,PSV and FIB in the observation group were(3.27±0.60)mPa·s,(5.09±1.36)mPa·s,(1.13±0.17)mPa·s,(3.51±1.58)g/L,were lower than that of the control group(4.02±0.78)mPas,(6.30±1.52)mPas,(1.35±0.26)mPa·s,(4.34±1.76)g/L(t=5.335,4.153,4.957,2.456,P<0.05).Conclusion Butylphthalide combined with intravenous thrombolysis in the treatment of acute cerebral infarction has a significant clinical effect,which can effectively improve the neurological function and hemorheology of patients.
作者
孙广珍
SUN Guang-Zhen(Third Internal Medicine Department of the Sixth Inpatient Department,General Hospital of Heilongjiang Agricultural Reclamation Administration,Harbin 150088,China)
出处
《中国药物经济学》
2023年第2期98-100,共3页
China Journal of Pharmaceutical Economics
关键词
急性脑梗死
丁苯酞
静脉溶栓
血液流变学
Acute cerebral infarction
Butyl phthalide
Intravenous thrombolysis
Hemorheology
