摘要
目的 探讨盐酸奥洛他定联合组织胺人免疫球蛋白治疗慢性荨麻疹的临床价值。方法 选取2019年10月至2020年11月朝阳市第二医院收治的慢性荨麻疹患者86例作为研究对象,采用随机数字表法分为观察组(n=43)与对照组(n=43)。对照组采用盐酸奥洛他定单独治疗,观察组在对照组基础上加用组织胺人免疫球蛋白治疗。比较两组疗效、病情评分、血清免疫球蛋白E(IgE)水平、症状改善情况、白细胞计数(WBC)、5-羟色胺(5-HT)水平及不良反应发生率。结果 观察组治疗有效率93.02%(40/43)较对照组74.42%(32/43)高(P<0.05);治疗后,观察组病情评分较对照组低(P<0.05);治疗后,观察组血清IgE水平较对照组低(P<0.05);治疗后,观察组瘙痒时间、持续发作时间较对照组少,风团直径较对照组短,差异有统计学意义(P<0.05);治疗后,观察组WBC水平较对照组低,5-HT水平较对照组高,差异有统计学意义(P<0.05);观察组不良反应发生率9.30%(4/43)与对照组11.63%(5/43)比较差异无统计学意义(P>0.05)。结论采用盐酸奥洛他定联合组织胺人免疫球蛋白治疗慢性荨麻疹,可提高疗效,改善免疫功能和临床症状,安全性高。
Objective To explore the clinical value of ololatadine hydrochloride combined with histamine human immunoglobulin in the treatment of chronic urticaria.Methods 86 patients with chronic urticaria admitted to the Second Hospital of Chaoyang City from October 2019 to November 2020 were selected as the study subjects.They were divided into observation group(n=43)and control group(n=43)by random number table method.The control group was treated with olloatadine hydrochloride alone,and the observation group was treated with histamine human immunoglobulin according to the control group.The efficacy,disease score,serum immunoglobulin E(IgE)level,symptom improvement,leukocyte(WBC),serotonin(5-HT)levels,and the incidence of adverse effects of two groups were compared.Results The effective rate of treatment in the observation group was 93.02%(40/43)higher than that in the control group 74.42%(32/43)(P<0.05);post-treatment,The condition score in the observation group was lower than in the control group(P<0.05);post-treatment,Serum IgE levels in the observed group were lower than in the control group(P<0.05);post-treatment,The observation group had less itching time and attack duration than the control group(P<0.05),the wind mass diameter was shorter than that in the control group(P<0.05);post-treatment,The WBC levels were lower in the observed group as compared with the control group(P<0.05),the 5-HT levels were higher than those in the control group(P<0.05);the incidence of adverse reactions in the observation group was 9.30%(4/43),compared with 11.63%(5/43)in the control group(P>0.05).Conclusion The combination of olatadine hydrochloride with histamine human immunoglobulin for the treatment of chronic urticaria can improve efficacy,improve immune function and clinical symptoms and have high safety.
作者
王铁
WANG Tie(Skin and Venereal Disease Department of Chaoyang City Second Hospital,Chaoyang 122000,China)
出处
《中国药物经济学》
2023年第2期75-78,82,共5页
China Journal of Pharmaceutical Economics
关键词
慢性荨麻疹
盐酸奥洛他定
组织胺人免疫球蛋白
疗效
Chronic urticaria
Olotadine hydrochloride
Histamine human immunoglobulin
Efficacy
