摘要
目的观察音乐联合降压药物干预高血压伴认知障碍的临床疗效,探讨其改善认知功能及相关症状的机制。方法选取2022年3—8月成都市第八人民医院收治的58例高血压伴认知障碍的患者为研究对象,按照随机数字表法分为对照组(n=30)和试验组(n=28)。对照组服用常规降压药物,试验组在对照组治疗基础上,每日上午聆听莫扎特《D大调双钢琴奏鸣曲》K.44845 min。两组均干预90 d。比较两组患者干预前后简易智能精神量表(MMSE)、医院用焦虑抑郁评分(HADS)、日常生活能力(Barthel指数)评分;比较两组患者血清雌二醇、多巴胺水平,肠道微生物菌群丰度变化及血压、心率值。结果试验组干预后MMSE评分高于对照组及干预前(P<0.05);HADS评分低于对照组及干预前(P<0.05);试验组干预后男性血清雌二醇、女性血清雌二醇和多巴胺水平均高于干预前及对照组(P<0.05);乳酸杆菌、双歧杆菌丰度均高于干预前及对照组(P<0.05)。结论音乐联合降压药物可以改善高血压伴认知障碍患者的认知状态和焦虑抑郁情绪,升高血清中雌二醇、多巴胺水平,提高肠道菌群中双歧杆菌和乳酸杆菌丰度。
Objective To observe the clinical efficacy of music therapy combined with antihypertensive drugs on hypertensive patients with cognitive impairment,and explore the mechanism of its improvement of cognitive function and related symptoms.Methods A total of 58 hypertensive patients with cognitive impairment admitted to Chengdu Eighth People's Hospital from March 2022 to August 2022 were selected as the study subjects.They were divided into control group(n=30)and experimental group(n=28)according to random number table method.The control group took conventional antihypertensive drugs,while the experimental group listened to Mozart's Sonata for Two Pianos in D Major K.448 for 45 min every morning on the basis of the treatment in the control group.The intervention lasted for 90 d.The scores of minimental state examination(MMSE),hospital anxiety and depression scale(HADS),and Barthel index of daily living ability before and after intervention were compared between the two groups.Levels of serum estradiol and dopamine,changes in the abundance of intestinal microflora,and values of blood pressure and heart rate were compared between the two groups.Results After intervention,the MMSE score in the experimental group was higher than that in the control group and that before intervention(P<0.05),the HADS score in the experimental group was lower than that in the control group and that before intervention(P<0.05).After intervention,serum estradiol of male patients,serum estradiol and dopamine of female patients in the experimental group were higher than those before intervention and those in the control group(P<0.05).After intervention,the abundance of Lactobacillus and Bifidobacterium in the experimental group was higher than that before intervention and that in the control group(P<0.05).Conclusion Music therapy combined with antihypertensive drugs can change the cognitive status and anxiety and depression in hypertensive patients with cognitive impairment,increase the serum levels of estradiol and dopamine,and improve the ab
作者
杨淞
汪瑞茹
郑凯旋
卢家春
费禹哲
汪怡婷
李茂全
Yang Song;Wang Ruiru;Zheng Kaixuan;Lu Jiachun;Fei Yuzhe;Wang Yiting;Li Maoquan(School of Public Health,Chengdu Medical College,Chengdu 610500,China;Qingbaijiang District Hospital of Traditional Chinese Medicine,Chengdu 610300,China;Chengdu Eighth People's Hospital,Chengdu 610083,China)
出处
《成都医学院学报》
CAS
2023年第2期224-228,共5页
Journal of Chengdu Medical College
基金
四川省中医药管理局项目资助(No:2018kf016)
四川省卫生健康委员会健康服务业项目资助(No:304946)。
关键词
认知障碍
音乐疗法
高血压
雌激素
多巴胺
肠道菌群
Cognitive impairment
Music therapy
Hypertension
Estrogen
Dopamine
Intestinal flora
