基于高分辨质谱的渔用非药品中隐形药物成分筛查分析

Screening analysis of hidden drugs in fishery nondrugs based on high resolution mass spectrometry

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摘要为了评估水产品养殖过程中渔用非药品的质量安全状况,采用高分辨质谱筛查技术,对上海市水产品养殖场、渔药商店以及网络平台的渔用非药品进行隐形药物成分筛查分析。结果表明,300份渔用非药品样品中,筛查出104个样品有隐形药物成分共189项次,含有15种药物成分,样品总筛出率为34.7%。按照筛出药物样品来源划分,渔药商店采集的样品检出率相对最低,为22.5%;养殖场次之,为25.3%;网络平台最高,为72.6%。按照筛出药物的性质划分,15种药物成分中包括农药6种,分别是扑草净、西草净、西玛津、多菌灵、敌百虫、乙氧喹啉;兽药8种,分别是恩诺沙星、乙酰甲喹、红霉素、加替沙星、氟苯尼考、磺胺嘧啶、环丙沙星、甲氧苄啶;水产停用药1种,为培氟沙星。按照样品中筛出药物种类划分,筛出含隐形药物的104个样品中,57个筛出单种药物,47个筛出2种及以上的药物,25个筛出3种及以上的药物,9个筛出4种及以上的药物,3个筛出5种及以上的药物,2个筛出6种药物。筛出药物的含量分布表明,61.9%的药物含量在100μg·kg^(-1)以上,最高可达1093023.26μg·kg^(-1)。研究表明,渔用非药品的来源以及其中隐形药物的种类及含量是养殖水产品中药物残留的主要原因之一,养殖户长期使用这类产品极有可能导致上市水产品中药物残留超标以及对养殖生态环境造成一定的污染。 Fishery nondrugs for aquaculture are important materials for production.Their quality is related to the sustainable development of aquaculture,as well as to the quality and safety of aquaculture products,food safety and ecological safety.In the long term,the Ministry of Agriculture and Rural Affairs has been paying great attention to the issue of aquaculture with input regulation,strictly adhering to the law for the production,operation and use of related products and other aspects of supervision and law enforcement.In order to evaluate the quality and safety of fishery nondrugs in the process of aquaculture,fishery nondrugs used in aquaculture in Shanghai area were studied in this paper.High resolution mass spectrometry screening technology was used to screen and analyze the hidden drug components of fishery nondrugs in aquaculture farms,fishery drug stores and network platforms in Shanghai,and to explore the harmfulness of pesticides and veterinary drugs in nondrugs fishery inputs to the quality and safety of aquatic products.From April 2020 to August 2020,a total of 300 fishery nondrug samples were collected in seven batches from various aquaculture farms and fishery pharmacies in Shanghai,and online platforms.According to the efficacy of their labels,the nondrugs collected for fishery use could be divided into 7 categories:water quality improver,sediment improver,antidote,microecological agents,impurity removal,growthpromoter agent and pesticide.The results showed that among 300 fishery nondrugs samples,189 unlabeled drug components were detected in 104 samples,including 15 drug components,and the total screening rate was 34.7%.According to the source of screened drug samples,the detection rate of samples collected from fishery pharmacy was the lowest,22.5%,followed by aquaculture farms,25.3%,and network platform was the highest,72.6%,three times that of the other two sources.Through onthespot visits and investigations,it is found that when farmers buy nonfishery drugs f

作者刘洋锋张海燕孔聪顾润润张楷文陈冈周俊芳沈晓盛 LIU Yangfeng;ZHANG Haiyan;KONG Cong;GU Runrun;ZHANG Kaiwen;CHEN Gang;ZHOU Junfang;SHEN Xiaosheng(College of Food Science,Shanghai Ocean University,Shanghai201306,China;East ChinaSea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Shanghai200090,China;Shanghai Jinshan District Aquatic Technology Promotion Station,Shanghai201599,China)

机构地区上海海洋大学食品学院中国水产科学研究院东海水产研究所上海市金山区水产技术推广站

出处《海洋渔业》 CSCD 北大核心 2023年第2期227-236,共10页 Marine Fisheries

基金上海市科技兴农重点攻关项目(2020-02-08-00-07-F01464) 上海市科委科技创新行动计划(18391901700)。

关键词高分辨质谱渔用非药品隐形药物筛查分析 high resolution mass spectrometry fishery nondrugs hidden drugs screening analysis

分类号 S948 [农业科学—水产养殖]