摘要
目的:分析抗IgLON5抗体相关脑炎的临床特征、发病机制、诊断及治疗,以提高临床医师对该疾病的认识。方法:收集1例抗IgLON5抗体相关脑炎患者的临床表现、影像学、免疫抗体、基因检测结果等资料,结合文献进行复习。结果:患者男性,61岁,主要临床表现为认知障碍、睡眠障碍、球麻痹和癫痫,脑脊液抗IgLON5抗体IgG阳性(1:100),血清抗IgLON5抗体IgG阳性(1:300),基因检测HLA单倍型HLA-DQB1*05:01-DRB1*10:01。入院后予激素冲击治疗、丙戊酸抗癫痫,症状明显改善。结论:本文报道1例以认知障碍、睡眠障碍、球麻痹和癫痫为主要表现抗IgLON5抗体相关脑炎,对激素治疗有反应。
Objective:To explore the clinical features,pathogenesis,diagnosis and treatment of Anti-IgLON5 disease in order to improve the understanding of Anti-IgLON5 disease.Methods:The clinical manifestations,images,immune antibodies,and genetic testing results of a patient with Anti-IgLON5 disease were collected,and reviewed according to literatures.Results:A 61-year-old male patient with the main clinical manifestations of cognitive impairment,somnipathy,bulbar paralysis and epilepsy,cerebro-spinal fluid anti-IgLON5 IgG antibody positive(1:100),serum anti-IgLON5 antibody IgG positive(1:300),HLA haplotype DQB1*05:01-DRB1*10:01.He had received high dosage corticosteroid and Sodium valproate for epilepsy,and he recovered significantly.Conclusion:This article reports a case of Anti-IgLON5 disease whose main manifestations are cognitive impairment,somnipathy,bulbar paralysis and epilepsy,and he gets benefit from corticosteroid..
作者
李才明
徐均洋
郑燕霞
陈绮莉
吴楚妍
邱志维
黄文城
Caiming LI;Junyang XU;Yanxia ZHENG;Qili CHEN;Chuyan WU;Zhiwei QIU;Wencheng HUANG(Department of neurology,the First People’s Hospital of Huizhou City,Huizhou 516003,China;Department of Clinical Medicine,the Second Clinical College of Medicine,Guangdong Medical University,Dongguan 523808,China)
出处
《阿尔茨海默病及相关病杂志》
2023年第1期12-14,共3页
Chinese Journal of Alzheimer's Disease and Related Disorders
基金
惠州市第一人民医院科研培育与创新基金项目(2020JC001)。
