摘要
血管生成素样蛋白4(angiopoietin-like 4,ANGPTL4)是血管生成素家族成员之一,在脂质代谢、葡萄糖稳态、炎症信号转导以及血管生成与血管渗透性中均起到调节作用。肿瘤微环境中炎症反应调控肿瘤进程,肿瘤血管生成在肿瘤生长转移中起至关重要的作用,因此ANGPTL4与肿瘤发生发展密切相关。多项研究显示,ANGPTL4在肿瘤生长、失巢凋亡抗性、肿瘤血管生成和肿瘤转移等过程中均起到重要的调节作用。本文对ANGPTL4在肿瘤进程中的作用作一综述。
Angiopoietin-like 4(ANGPTL4)is one of the angiopoietin family members and plays a regulatory role in lipid metabolism,glucose homeostasis,inflammatory signal transduction,angiogenesis and vascular permeability.Inflammatory reaction in tumor microenvironment regulates tumor progression,and tumor angiogenesis plays a vital role in tumor growth and metastasis,so ANGPTL4 is closely related to tumor occurrence and development.Many studies have shown that ANGPTL4 plays an important regulatory role in tumor growth,anoikis resistance,tumor angiogenesis and tumor metastasis.This paper reviews the role of ANGPTL4 in tumor progression.
作者
徐金歌(综述)
王志云
杨英(审校)
XU Jinge;WANG Zhiyun;YANG Ying(College of Life Science,Tianjin University,Tianjin 300072,China;不详)
出处
《中国生物制品学杂志》
CAS
CSCD
北大核心
2023年第3期373-378,共6页
Chinese Journal of Biologicals
基金
国家重点研发计划(2017YFA0205102)。
