摘要
目的:研究急性脑梗死(ACI)中医证候与颈动脉粥样硬化(CAS)及神经功能缺损程度、日常生活活动能力的相关性,进一步明确急性脑梗死发病的危险因素。方法:收集2020年8月~2022年1月福建中医药大学附属福州中医院符合纳入标准急性脑梗死住院患者80例,采集患者性别、年龄、基础病史等四诊资料,并进行风、火、痰、瘀、气虚、阴虚6个基本证候评分。结果:ACI合并CAS的发生与性别无相关关系(r=0.006,P=0.933),差异无统计学意义(P>0.05);ACI合并CAS的发生与年龄存在负相关关系(r=-0.154,P=0.030),差异有统计学意义(P<0.05)。高血压、高血脂、糖尿病影响CAS的程度(χ^(2)=28.342,P=0.001),差异有统计学意义(P<0.05)。ACI合并CAS 80例患者中医证候中瘀证56例(70.0%)、痰证51例(63.8%)、阴虚证42例(52.5%)、风证40例(50.0%)、火证35例(43.8%)、气虚证22例(27.5%),中风各证候发生频率依次为瘀证、痰证、阴虚证、风证、火证、气虚证。神经功能缺损程度、日常生活活动能力与颈动脉粥样硬化相比,日常生活活动能力评分(ADL)与CAS分级之间存在负相关关系(r=-0.243,P=0.030),差异有统计学意义(P<0.05);神经功能缺损评分(NIHSS)与CAS分级之间无相关关系(r=0.61,P=0.589),差异无统计学意义(P>0.05);CAS分级与ACI中医证候统计学分析,差异有统计学意义(P<0.01)。CAS与ACI中医证候有直线相关,即与CAS合并ACI中医证候分型有线性关系的有阴虚证、气虚证证候,其直线回归方程显示分别为Y=2.132+0.726×3、Y=2.345+0.610×6。结论:ACI患者年龄、高血压、高脂血症、糖尿病等基础病史与颈动脉粥样硬化的发生相关;中风基本证候发生率以瘀证、痰证分布最多;ACI合并CAS与阴虚证、气虚证成正相关;ADL与CAS存在负相关关系,影响ACI日常生活活动能力,为急性脑梗死的中医证候提供了客观依据。
Objective To study the correlation of TCM syndrome of acute cerebral infarction with carotid atherosclerosis and neurological deficit,and the ability of daily life activities,and clarifies the risk factors of acute cerebral infarction.Method From August,2020 to January,2022,80 patients in Fuzhou Hospital of Traditional Chinese Medicine affiliated to Fujian University of Traditional Chinese Medicine that met the inclusion criteria for acute cerebral infarction were collected.Sex,age and basic medical history were collected,and six basic syndrome scores of wind,fire,phlegm,blood stasis,qi deficiency and Yin deficiency were scored.Results There was no correlation between ACI with CAS and sex(r=0.006,P=0.933),with no significant difference(P>0.05);a negative association between ACI with CAS and age(r=-0.154,P=0.030)and a significant difference(P<0.05).The degree of hypertension,hyperlipidemia,and diabetes affecting CAS(χ^(2)=28.342,P=0.001),the difference was statistically significant(P<0.05).Among the 80 patients with ACI combined with CAS,there were 56(70.0%)cases of blood stasis syndrome,51(63.8%)cases of phlegm syndrome,42(52.5%)cases of yin deficiency syndrome,40(50.0%)cases of wind syndrome,35(43.8%)cases of fire syndrome,and 22(27.5%)cases of qi deficiency syndrome,the frequency of each syndrome of stroke was in order as follows:blood stasis syndrome,phlegm syndrome,yin deficiency syndrome,wind syndrome,fire syndrome,and qi deficiency syndrome.Compared with carotid atherosclerosis,there was a negative correlation between ADL and CAS grades(r=-0.243,P=0.030),the difference was statistically significant(P<0.05),no correlation between NIHSS and CAS(r=0.61,P=0.589),the difference was not statistically significant(P>0.05),CAS Classification and Statistical Analysis of TCM Syndromes in ACI,the difference was statistically significant(P<0.01).CAS has a linear correlation with ACI TCM syndrome,that is,Yin deficiency syndrome with CAS and ACI TCM syndrome classification,and its linear regression equation shows Y=2.132
作者
念峰
黄文
陈颖萍
NIAN Feng;HUANG Wen;CHEN Ying-ping(Emergency Department,Fuzhou Hospital of Traditional Chinese Medicine affiliated to Fujian University of Traditional Chinese Medicine,Fuzhou 350001,China)
出处
《吉林医学》
CAS
2023年第4期884-887,共4页
Jilin Medical Journal
基金
福建中医药大学校管科研课题[项目编号:XB2020079]。
