摘要
多发性骨髓瘤(multiple myeloma,MM)作为血液系统第二大常见的恶性肿瘤,尽管在近几十年其疗效取得了重大提升,然而目前仍无法治愈。研究发现这与免疫微环境中细胞与非细胞成分,如间充质基质细胞介导免疫逃逸,破骨细胞活性增高,成骨细胞分化受损及免疫细胞、细胞因子的免疫功能异常促进骨髓瘤细胞的增殖、存活和耐药密切相关,与此同时还伴随许多新型治疗工具的产生。因此,深入探究上述成分与骨髓瘤细胞相互作用,有望为MM的临床治疗提供新思路和策略。
Multiple myeloma is the second most common hematological malignancy,there is still no cure for it despite the great progress on its treatment in decades.This is found to be closely related to the cellular and non-cellular components in the immune microenvironment.For instance,the mesenchymal stromal cells in the immune microenvironment could mediate the immune escape,increase the osteoclast activity,and impaire the osteoblast differentiation.In addition,some immune cells and cytokines with abnormal immune function could promote the proliferation,survival and drug resistance of myeloma cells.In recent years,many new therapeutic tools has emerged.Therefore,an in-depth study of the interaction between the above components and myeloma cells is expected to provide some new ideas and strategies for the clinical treatment of multiple myeloma.
作者
吴秀英
常进
WU Xiuying;CHANG Jin(Department of Hematology,the Fifth Clinical Medical College of Shanxi Medical University,Taiyuan,030012,China)
出处
《医学分子生物学杂志》
CAS
2023年第2期184-188,共5页
Journal of Medical Molecular Biology
关键词
多发性骨髓瘤
免疫微环境
骨髓间充质基质细胞
破骨细胞
免疫细胞
multiple myeloma
immune microenvironment
bone marrow mesenchymal stromal cells
osteoclasts
immune cells
