摘要
大多数人的眼表存在着相对稳定的微生物群落,微环境的改变与眼表健康状态密切相关。16S rDNA/rRNA高通量测序技术的使用大大提升了对眼表微生物群落的认识。人类眼睛,尤其是结膜直接暴露在不断变化的环境中,了解眼表菌群是否存在可识别的微生物群差异非常重要,这些差异有助于解释眼表疾病的地理多样性。该文为应用16S rDNA/rRNA高通量测序对眼表疾病地理多样性进行阐释提供了新思路。
Most people′s ocular surface hosts relatively stable microbial communities,and the change of microenvironment is closely related to the health of ocular surface.The use of 16S rDNA/rRNA high-throughput sequencing technology has greatly improved the understanding of microbial communities of the ocular surface.The human eyes,especially the conjunctiva,are directly exposed to the ever-changing environments,and it is important to know if there are identifiable microbiome differences in the ocular surface flora,which is helpful to explain the geographic diversity of ocular surface diseases.This paper provides a new way to interpret the geographical diversity of ocular surface diseases by 16S rDNA/rRNA high-throughput sequencing.
作者
李周瑜(综述)
胡柯
万文娟
计岩(审校)
LI Zhouyu;HU Ke;WAN Wenjuan;JI Yan(Department of Ophthalmology/Key Laboratory of Ophthalmology,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)
出处
《现代医药卫生》
2023年第7期1170-1174,共5页
Journal of Modern Medicine & Health
基金
重庆市科技局面上基金项目(cstc2020jcyjmsxmX0829)
重庆市教育委员会科技项目(KJQN202000445)。
关键词
眼表菌群
微生物地理多样性
16S
rDNA高通量测序
综述
Ocular surface flora
Microbial geographical diversity
16S rDNA/rRNA high-throughput sequencing
Review
