摘要
【目的】探讨热休克转录因子2(HSF2)、白细胞介素-23(IL-23)、髓样树突状细胞(MDC)在溃疡性结肠炎(UC)病情评估中的应用价值。【方法】选取2019年6月至2021年8月本院收治的146例UC患者(观察组),另选取73例同期健康体检志愿者作为对照组,比较观察组入院时、对照组体检时及不同病情UC患者血清HSF2、IL-23、MDC水平,采用Pearson分析上述指标与患者病情相关性,采用受试者工作特征曲线(ROC曲线)分析其对UC的诊断价值。【结果】观察组血清HSF2、IL-23、MDC水平高于对照组,差异有统计学意义(P<0.05)。活动期组患者血清HSF2、IL-23、MDC水平高于缓解期组,差异有统计学意义(P<0.05)。三组患者血清HSF2、IL-23、MDC水平比较,重度组>中度组>轻度组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,血清HSF2、IL-23、MDC水平与发作时期、病情程度均呈正相关(均P<0.05)。ROC曲线分析显示,血清HSF2、IL-23、MDC水平对UC诊断的曲线下面积(AUC)分别为0.795、0.832、0.856,联合诊断AUC为0.927,大于单一指标(P<0.05)。【结论】血清HSF2、IL-23、MDC水平对UC患者病情严重程度具有一定评估价值,可为临床早期诊断UC提供参考。
【Objective】To investigate the value of heat shock transcription factor 2(HSF2),interleukin 23(IL-23),and myeloid dendritic cells(MDC)in the evaluation of ulcerative colitis.【Methods】A total of 146 patients with UC admitted to our hospital from June 2019 to August 2021(observation group)were selected,and another 73 healthy volunteers were selected as the control group.The serum levels of HSF2,IL-23,and MDC were compared between the observation group,the control group,and patients with UC of different conditions at admission.Pearson was used to analyze the correlation between the above indicators and the patient's condition,and the diagnostic value of the receiver operational characteristic curve(ROC curve)was used to analyze its diagnostic value for UC.【Results】The serum levels of HSF2,IL-23,and MDC in the observation group were significantly higher than those in the control group(P<0.05).The serum levels of HSF2,IL-23,and MDC in the active phase group were significantly higher than those in the remission phase group(P<0.05).The levels of serum HSF2,IL-23,and MDC in the three groups of patients were statistically significant(P<0.05).Pearson correlation analysis showed that the serum levels of HSF2,IL-23,and MDC were positively correlated with the onset period and severity of the disease(all P<0.05).The ROC curve analysis showed that the area under the curve(AUC)of serum HSF2,IL-23,and MDC levels for the diagnosis of UC was 0.795,0.832,and 0.856,respectively.The combined diagnosis AUC was 0.927,which was greater than a single indicator(P<0.05).【Conclusion】The serum levels of HSF2,IL-23,and MDC have certain evaluation value for the severity of UC patients,and can provide a reference for the clinical early diagnosis of UC.
作者
宋美楠
SONG Mei-nan(Puyang Oilfield General Hospital,Puyang Henan 457001)
出处
《医学临床研究》
CAS
2023年第3期367-369,373,共4页
Journal of Clinical Research
