摘要
目的观察有氧运动改善急性心肌梗死伴心衰患者心功能、血管内皮功能及生存质量的价值。方法按照随机数字表法将武汉亚洲心脏病医院心外科2019年1月—2021年1月收治的110例急性心肌梗死伴心衰患者均分为观察组(55例)和对照组(55例)。对照组给予患者利尿、β受体阻滞剂、抗凝及抗血小板聚集等常规治疗,观察组在对照组基础上开展有氧运动,持续运动6个月,观察疗效。比较两组治疗前后心功能指标参数[左心室收缩末期内径(LVESD)、左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、舒张早期/舒张晚期左房室瓣血流速度(E/A比值)],对比血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)]水平,采用西雅图心绞痛量表(SAQ)评价患者的生活质量,记录主要心血管不良事件(MACE)。结果两组治疗后LVESD、LVEDD均低于治疗前,LVEF、E/A比值均高于治疗前(均P<0.05),观察组治疗后LVESD、LVEDD均低于对照组,LVEF、E/A比值均高于对照组(均P<0.05);两组治疗后NO高于治疗前,ET-1低于治疗前(均P<0.05),观察组治疗后NO高于对照组,ET-1低于对照组(均P<0.05);两组治疗后SAQ各维度评分高于治疗前,观察组治疗后SAQ各维度评分高于对照组(均P<0.05);观察组患者MACE总发生率为7.27%(4/55),显著低于对照组21.82%(12/55),差异有统计学意义(均P<0.05)。结论有氧运动可有效提高急性心肌梗死伴心衰患者的心功能、改善血管内皮功能、提高患者生存质量,值得临床推广。
Objective To observe the value of aerobic exercise in improving cardiac function,vascular endothelial function and quality of life in patients with acute myocardial infarction with heart failure.Methods According to the random number table method,110 patients with acute myocardial infarction with heart failure treated in the Department of Cardiology of Wuhan Asian heart disease hospital from January 2019 to January 2021 were divided into observation group(55 cases)and control group(55 cases).The control group was given diuretic,β-blocker,anticoagulant and antiplatelet aggregation and other conventional treatment,and the observation group was also given aerobic exercise on the basis of the control group for 6 months to observe the efficacy.Cardiac function parameters were compared between the two groups before and after treatment left ventricular end-systolic dimension(LVESD),left ventricular end diastolic diameter(LVEDD),left ventricular ejection fraction(LVEF),E/A ratio,contrast vascular endothelial function indexes[nitric oxide(no),endothelin-1(ET-1)],and Seattle Angina Pecina Questionnaire(SAQ)was used to evaluate the life quality.Major adverse cardiovascular events(MACE)was recorded.Results After treatment,the left ventricular end systolic dimension(LVESD)and left ventricular end diastolic dimension(LVEDD)of the two groups were lower than those before treatment,Left ventricular ejection fraction(LVEF)and early diastolic/late diastolic left atrioventricular valve flow velocity(E/A ratio)was higher than before treatment(all P<0.05).The LVESD and LVEDD after treatment of the observation group were significantly lower than those of the control group,and the LVEF and E/A ratio after treatment of the observation group were both significantly higher than those of the control groups(all P<0.05).The NO levels after treatment of these 2 groups were both significantly higher than those before treatment,and the ET-1 levels after treatrment of these groups were both significantly lower than those before treatment(all P<0
作者
彭齐
杨琴
胡国智
薛军
杨小菊
PENG Qi;YANG Qin;HU Guozhi;XUE Jun;YANG Xiaoju(Department of Cardiac Surgery,Wuhan Asian Heart Hospital,Wuhan Hubei 430015,China)
出处
《中国急救复苏与灾害医学杂志》
2023年第3期298-301,共4页
China Journal of Emergency Resuscitation and Disaster Medicine
基金
湖北省卫生健康委青年项目(编号:WJ2019Q043)。
关键词
有氧运动
急性心肌梗死
心衰
血管内皮功能
生存质量
Aerobic exercise
Acute myocardial infarction
Heart failure
Vascular endothelial function
Quality of life
