摘要
目的 观察清肝利肠方敷脐治疗酒精性肝硬化腹水湿热水停证的临床疗效。方法 选取2019年3月—2019年12月期间在首都医科大学附属北京佑安医院门诊及病房就诊治疗的酒精性肝硬化腹水患者50例,借助SAS统计软件,治疗组与对照组按照1∶1比例随机分组,盲底密封,交临床试验负责单位妥善保存,根据随机数码表列出的流水号进行治疗分配。治疗组和对照组各有2例失访,对照组另有1例因病情需要,进行腹腔穿刺后放腹水治疗,最后纳入统计共45例。将45例酒精性肝硬化腹水湿热水停证患者随机分为治疗组23例和对照组22例,两组患者均给予西医对症基础治疗,对照组在基础治疗上加安慰剂敷脐治疗,治疗组在基础治疗上给予清肝利肠方敷脐治疗,两组患者均神阙穴敷贴治疗10 h/d。连续治疗4周后,观察比较两组患者总体疗效、中医证候疗效、中医证候积分、体质量、腹围、腹水量变化及安全性。结果 治疗后治疗组总有效率82.6%(19/23)优于对照组72.7%,差异无统计学意义(P>0.05)。治疗后治疗组中医证候总有效率95.7%(22/23)优于对照组72.7%(16/22),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组中医证候积分较对照组明显降低,差异有统计学意义(P<0.05)。治疗后两组患者体质量、腹围变化情况较治疗前降低,差异有统计学意义(P<0.05);且治疗组体质量、腹围变化低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后腹水严重程度比较,差异无统计学意义(P>0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论 中药敷脐治疗是辅助治疗肝硬化腹水的中医特色疗法之一,该疗法有助于酒精性肝硬化腹水的治疗,能够明显改善中医证候,提高患者满意度,增加治疗依从性。
Objective To observe the clinical effect of navel application of Qinggan Lichang Prescription on ascites in alcoholic cirrhosis(syndrome of dampness-heat and water retention).Methods A total of 50 alcoholic cirrhosis patients with ascites treated in Beijing You'an Hospital affiliated to Capital Medical University from March to December in 2019 were included.SAS was employed to randomly assign the patients into an observation group and a control group at a ratio of 1∶1.The blinding information was sealed and stored by the organization for clinical trials.The patients were labeled for treatment according to the random number table.Two patients dropped off respectively in both groups,and one patient in the control group received paracentesis for ascites.Finally,45 patients were enrolled for analysis,including 23 patients in the observation group and 22 patients in the control group.Both groups received symptomatic basic treatment of western medicine.The observation group and the control group additionally received navel application of Qinggan Lichang Prescription and placebo,respectively,at Shenque(CV 8)for 10 h/d.The treatment lasted for 4 weeks,and the total clinical efficacy,clinical efficacy on TCM syndrome,TCM syndrome score,body weight,abdominal circumference,peritoneal fluid volume,and safety were compared between the two groups.Results The total effective rate of the observation group was 82.6%(19/23),which was higher than that(72.7%)of the control group(P=0.724>0.05).The effect rate on TCM syndrome in the observation group was 95.7%(22/23),which was higher than that(72.7%,16/22)in the control group (P =0.042 <0.05).The TCM syndrome score,body weight,and abdominal circumference in both groups decreased aftertreatment,and the values in the observation group was lower than those in the control group(P <0.05).The peritoneal fluid volume showed no significant difference before and after treatment(P >0.05).During the treatment,the incidence of adverse reactions showed no significant difference between the two g
作者
许文君
李晶滢
张纯
XU Wen-jun;LI Jing-ying;ZHANG Chun(Beijing You'an Hospital,Capital Medical University,Beijing 100069;Peking University Third Hospital,Beijing 100191)
出处
《世界中西医结合杂志》
2023年第3期584-587,592,共5页
World Journal of Integrated Traditional and Western Medicine
基金
北京市属医院科研培育计划项目(PZ2016009)。
关键词
酒精性肝硬化
肝硬化腹水
清肝利肠方
敷脐疗法
随机对照研究
Alcoholic Cirrhosis
Ascites Due to Cirrhosis
Qinggan Lichang Prescription
Navel Application Therapy
Randomized Controlled Study
