摘要
目的了解1990—2019年江苏省白血病疾病负担变化趋势,为江苏省白血病防制工作提供依据。方法通过2019年全球疾病负担研究(GBD 2019)数据库收集1990—2019年江苏省白血病患病率、发病率、死亡率和伤残调整寿命年(DALY)率等资料,并采用2000年中国人口年龄结构标化。计算平均年度变化百分比(AAPC)分析白血病疾病负担变化趋势。结果1990—2019年江苏省白血病年均标化患病率、标化发病率、标化死亡率和标化DALY率分别为63.63/10万、9.76/10万、4.10/10万和194.83/10万。1990—2019年江苏省白血病标化患病率(AAPC=1.420%,t=5.644,P<0.001)和标化发病率呈上升趋势(AAPC=0.806%,t=3.505,P<0.001);标化死亡率(AAPC=-1.589%,t=-14.714,P<0.001)和标化DALY率(AAPC=-1.849%,t=-9.046,P<0.001)呈下降趋势。男性年均标化患病率、标化发病率、标化死亡率和标化DALY率分别为65.27/10万、10.32/10万、4.69/10万和216.94/10万,高于女性的62.38/10万、9.29/10万、3.57/10万和172.80/10万(均P<0.05)。白血病粗患病率在0~<15岁和60~<75岁达到高峰;粗发病率、粗死亡率和粗DALY率在0~<15岁和≥75岁达到高峰。结论1990—2019年江苏省白血病死亡率和DALY率呈下降趋势,患病率和发病率呈上升趋势;男性、儿童和老年人的白血病疾病负担较重。
Objective To investigate the trends in the disease burden of leukemia in Jiangsu Province from 1990 to 2019,so as to provide insights into leukemia control in Jiangsu Province.Methods The prevalence,incidence,death and disability adjusted life years(DALYs)of leukemia in Jiangsu Province from 1990 to 2019 were retrieved from the 2019 Global Burden of Disease Study(GBD 2019)database,and standardized by the age structure of Chinese popula⁃tions in 2000.The trends in the disease burden of leukemia in Jiangsu Province from 1990 to 2019 were analyzed us⁃ing average annual percent change(AAPC).Results The average annual standardized prevalence,incidence,mortality and DALY rate of leukemia were 63.63/105,9.76/105,4.10/105 and 194.83/105 in Jiangsu Province from 1990 to 2019,respectively.The average annual standardized prevalence(AAPC=1.420%,t=5.644,P<0.001)and incidence(AAPC=0.806%,t=3.505,P<0.001)of leukemia appeared a tendency towards a rise,while the average annual standardized mor⁃tality(AAPC=-1.589%,t=-14.714,P<0.001)and DALY rate(AAPC=-1.849%,t=-9.046,P<0.001)of leukemia ap⁃peared a tendency towards a decline in Jiangsu Province from 1990 to 2019.Higher average annual standardized preva⁃lence(65.27/105 vs.62.38/105,P<0.001),incidence(10.32/105 vs.9.29/105,P<0.001),mortality(4.69/105 vs.3.57/105,P<0.001)and DALY rate of leukemia(216.94/105 vs.172.80/105,P<0.001)were estimated among men than among women.The crude prevalence of leukemia peaked among patients at ages of 0 to 14 years and 60 to 74 years,and the crude incidence,DALY rate and mortality of leukemia peaked at ages of 0 to 14 years and 75 years and older.Con⁃clusions The mortality and DALY of leukemia appeared a tendency towards a decline and the prevalence and inci⁃dence appeared a tendency towards a rise in Jiangsu Province from 1990 to 2019;however,there were high disease burdens of leukemia among men,children and the elderly.
作者
马昭君
李伟伟
董建梅
周金意
韩仁强
秦绪成
MA Zhaojun;LI Weiwei;DONG Jianmei;ZHOU Jinyi;HAN Renqiang;QIN Xucheng(Department of Chronic Non-communicable Diseases Control and Prevention,Lianyungang Center for Disease Control and Prevention,Lianyungang,Jiangsu 222003,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing,Jiangsu 210029,China)
出处
《预防医学》
2023年第4期282-285,290,共5页
CHINA PREVENTIVE MEDICINE JOURNAL
基金
江苏省卫生计生委预防医学科研课题(Y2015030)。
关键词
白血病
疾病负担
伤残调整寿命年
leukemia
burden of disease
disability adjusted life years
