摘要
目的 探讨温州市不同区域大气细颗粒物(PM2.5)暴露水平对喘息性疾病患儿肺功能及白细胞介素-6(IL-6)水平的影响。方法 选取2017年10月—2021年6月在温州市的320例喘息性疾病患儿作为研究对象,根据所属不同地区分为城区组(市区,n=80)、工业区组(瓯海,n=80)、渔区组(洞头,n=80)及山区组(泰顺,n=80)。检测并比较不同地区患儿1周内PM2.5暴露水平、肺功能[潮气量(VT)、吸呼比(Ti/Te)、达峰时间比(tPTEF/tE)与达峰容积比(vPTEF/vE)]及IL-6水平,并采用Pearson相关性分析PM2.5暴露水平与肺功能及IL-6水平相关性。结果 不同地区患者心率、动脉血氧饱和度及呼吸频率相比差异无统计学意义(P>0.05);不同地区患儿PM2.5暴露水平及IL-6水平相比,工业区组最高,城区组次之,随后为山区组及渔区组(P<0.05);不同地区患儿VT水平相比差异无统计学意义(P>0.05);不同地区患儿Ti/Te、tPTEF/tE及vPTEF/vE水平相比,其中渔区组最高,山区组次之,随后是工业区组及城区组(P<0.05);不同地区患者PM2.5暴露水平均与IL-6水平及tPTEF/tE水平成正相关关系(P<0.05)。结论 PM2.5暴露水平为诱导患儿发生喘息性疾病的诱因之一,并且其可影响患者肺功能,同时测定IL-6水平可反馈患儿近期PM2.5暴露水平,在临床上具有应用价值。
Objective This paper aims to investigate the effects of atmospheric fine particulate matter(PM2.5) levels in different regions of Wenzhou City on pulmonary function and interleukin-6(IL-6) levels in children with asthmatic diseases. Methods A total of 320 children with asthmatic disease in Wenzhou were selected from October 2017 to June 2021 as the research objects, and divided into urban group(urban area, n=80) and industrial area group(Ouhai, n=80), fishing area group(Dongtou, n=80) and mountain group(Taishun, n=80). The PM2.5 level, pulmonary function [tidal volume(VT), respiratory-to-expiratory ratio(Ti/Te), time-to-peak ratio(tPTEF/tE) and volume-to-peak ratio(vPTEF/vE)] and IL-6 levels were detected and compared. Pearson correlation was used to analyze the correlation between PM2.5 levels and pulmonary function and IL-6 levels. Results There was no statistical significance on the difference in heart rate, arterial oxygen saturation and respiratory rate among patients in different regions(P>0.05). Compared with the PM2.5 levels and IL-6 levels of children in different areas, the industrial area group was the highest, followed by the urban area group, the mountainous area group and the fishing area group(P<0.05);there was no statistical significance on the difference in VT levels in children from different regions(P>0.05);compared with the levels of Ti/Te, tPTEF/tE and vPVEF/vE in children from different regions, the fishing group was the highest, followed by the mountain group, the industrial group and the urban group(P<0.05);PM2.5 exposure levels were positively correlated with IL-6 levels and tPTEF/tE levels in patients from different regions(P<0.05). Conclusion The exposure level of PM2.5 is one of the inducements to induce asthmatic disease in children, and it can affect the lung function of patients. At the same time, measuring the level of IL-6 can feedback the recent exposure level of PM2.5 in children, which has clinical application value.
作者
宋显相
叶攀峰
郑春秋
张潮
王璐璐
姜毅
SONG Xian-xiang;YE Pan-feng;ZHENG Chun-qiu;ZHANG Chao;WANG Lu-lu;JIANG Yi(Department of Pediatrics,Wenzhou People's Hospital,Zhejiang 325000,China)
出处
《中国卫生检验杂志》
CAS
2023年第5期568-571,共4页
Chinese Journal of Health Laboratory Technology
基金
温州市科技计划项目(Y20170619)。
关键词
大气细颗粒物
患儿
喘息性疾病
肺功能
白细胞介素-6
Atmospheric fine particulate matter
Children
Wheezing disease
Lung function
Interleukin-6
