摘要
应激会导致抑郁,而运动对治疗抑郁是有益的,但这些作用的机制尚未被阐明。随着大数据时代的到来和生物信息技术的革新,通过比较基因的表达差异揭示疾病发生的分子机制逐渐成为高通量研究的常用策略。基因表达芯片可帮助研究者获取大量的抑郁相关基因信息,其中差异表达基因(differentially expressed genes,DEGs)是指抑郁或抑郁共病患者与正常人相比、治疗进行和运动干预前后,在转录组水平上表达有显著性差异的基因。综述研究发现,NDUFB9、CAMK2A、CACNA1D、NTRK2、CTSW、HES1、EGR1、NRN1、VEGF、GCC2等基因在抑郁发病机制、治疗机制、共病机制和运动干预机制中重复出现,且存在密切联系。生物信息分析结果显示,这些基因涉及能量代谢、氧化应激、表观遗传、炎症免疫、神经生长和发育、细胞生长存活与功能维持以及磷脂酰肌醇信号、Notch信号等相关功能和通路。
Stress can lead to depression,and exercise is beneficial for the treatment of depression,but the mechanism has not been clarified.With the advent of the era of big data and the innovation of bioinformation technologies,comparing gene expression differences to reveal the molecular mechanism of diseases has gradually become a common strategy for high-throughput research.The gene expression microarray can help researchers to obtain large amounts genetic information related to depression,these differentially expressed genes are those genes that are significantly differentially expressed at the transcriptome level in patients with depression or depressive comorbiditis compared with healthy subjects,before and after treatment and exercise intervention.This study reviews that NDUFB9,CAMK2A,CACNA1D,NTRK2,CTSW,HES1,EGR1,NRN1,VEGF,GCC2 and other genes showed close contact or overlap in the mechanisms involved pathogenesis,treatments,comorbidities and exercise intervention for depression.Bioinformatics analysis showed that these genes are associated with energy metabolism,oxidative stress,epigenetics,inflammatory immunity,nerve growth and development,cell growth,survival and functional maintenance,phosphatidylinositol signaling,Notch signaling and other related functions and pathways.
作者
刘文彬
漆正堂
刘微娜
LIU Wenbin;QI Zhengtang;LIU Weina(Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,East China Normal University,Shanghai 200241,China;School of Physical Education and Health Care,East China Normal University,Shanghai 200241,China)
出处
《中国体育科技》
北大核心
2023年第3期37-43,共7页
China Sport Science and Technology
基金
国家自然科学基金项目(31871208)
上海市自然科学基金项目(18ZR1412000)
中央高校基本科研业务费专项资金项目(40500-21203-542500/006/004)
华东师范大学优秀博士生学术创新能力提升计划项目(YBNLTS2021-022)。
关键词
基因表达芯片
差异表达基因
生物信息学
抑郁
运动干预
gene expression chip
differentially expressed genes
bioinformatics
depression
exercise intervention
