摘要
Skeletal tissue is highly innervated.Although different types of nerves have been recently identified in the bone,the crosstalk between bone and nerves remains unclear.In this review,we outline the role of the peripheral nervous system(PNS)in bone regeneration following injury.We first introduce the conserved role of nerves in tissue regeneration in species ranging from amphibians to mammals.We then present the distribution of the PNS in the skeletal system under physiological conditions,fractures,or regeneration.Furthermore,we summarize the ways in which the PNS communicates with bone-lineage cells,the vasculature,and immune cells in the bone microenvironment.Based on this comprehensive and timely review,we conclude that the PNS regulates bone regeneration through neuropeptides or neurotransmitters and cells in the peripheral nerves.An in-depth understanding of the roles of peripheral nerves in bone regeneration will inform the development of new strategies based on bone-nerve crosstalk in promoting bone repair and regeneration.
基金
National Science Foundation of China(No.82002313,No.82072444)
National Key Research&Development Program of China(2021YFA1101503,2018YFC2001502 and 2018YFB1105705)
Department of Science and Technology of Hubei Province(No.2020BCB004)
University Grants Committee,Research Grants Council of the Hong Kong Special Administrative Region,China(14121721,14108720,C7030-18G,T13-402/17-N and Ao E/M-402/20)
Wuhan Union Hospital“Pharmaceutical Technology nursing”special fund(No.2019xhyn021)。
