摘要
免疫治疗是当前最受关注的肿瘤治疗方式之一,免疫检查点抑制剂、细胞治疗和肿瘤疫苗等免疫治疗手段,在临床上取得了重要进展。近年来,除了以单抗药物为代表的免疫检查点抑制剂以外,多肽药物也逐渐受到关注。本文着重总结多肽药物在免疫检查点抑制剂方面的研究进展及应用,包括单靶点多肽阻断剂、双功能多肽阻断剂、自组装多肽,以及免疫检查点多肽在肿瘤诊断中的应用等,并对多肽药物目前面临的瓶颈问题提出思考,为多肽药物在肿瘤免疫治疗中的应用提供新的思路。
Immunotherapy has emerged as the most widely used cancer treatment strategy.Immune checkpoint blockade,cell therapy,and tumor vaccines have all achieved remarkable progress in clinical trials.Over recent years,monoclonal antibodies and peptide drugs have gained increasing attention as representatives for immune checkpoint blockades.This review summarized the research progress and application of peptide drugs targeting immune checkpoints,including single-target peptide blockers,bifunctional peptide blockers,and self-assembled peptides,as well as the application of peptides targeting immune checkpoints in cancer diagnosis.In addition,we offer new ideas to the bottleneck faced by peptide drugs for application in cancer immunotherapy.
作者
牛潇爽
胡争
周秀曼
高艳锋
Xiaoshuang Niu;Zheng Hu;Xiuman Zhou;Yanfeng Gao(School of Pharmaceutical Sciences(Shenzhen),Sun Yat-Sen University,Shenzhen 518107,China)
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2023年第6期271-277,共7页
Chinese Journal of Clinical Oncology
基金
国家自然科学基金项目(编号:U20A20369)资助。
关键词
肿瘤
免疫治疗
多肽药物
免疫检查点
cancer
immunotherapy
peptide drugs
immune checkpoint
