摘要
目的研究乌司他丁联合奥曲肽治疗胰腺炎的临床疗效。方法抽取2020年2月至2021年1月新乡医学院第三附属医院收治的胰腺炎患者102例,按照随机数字表法分为单一组和联合组,每组51例。单一组给予奥曲肽治疗,联合组在单一组基础上给予乌司他丁治疗。比较两组临床疗效、症状缓解时间、血清炎症因子[C反应蛋白(CRP)、白细胞介素-6(IL-6)、降钙素原(PCT)]水平、血红蛋白(Hb)、白蛋白(Alb)及不良反应发生率。结果联合组总有效率(96.08%,49/51)高于单一组(78.43%,40/51),P<0.05;联合组腹胀缓解时间、腹痛缓解时间、血淀粉酶恢复时间、进食恢复时间均短于单一组(P均<0.05)。治疗后,联合组CRP、IL-6、PCT水平均低于单一组(P均<0.05),Hb、Alb水平高于单一组(P<0.05)。联合组不良反应发生率(1.96%,1/51)低于单一组(15.69%,8/51),P<0.05。结论乌司他丁联合奥曲肽治疗胰腺炎患者,可缩短症状缓解时间,减轻机体炎症,提高Hb、Alb水平,并可提高临床疗效和安全性。
Objective To study the clinical effect of ulinastatin combined with octreotide on pancreatitis.Methods A total of 102 patients with pancreatitis treated in the Third Affiliated Hospital of Xinxiang Medical University from February 2020 to January 2021 were selected,and they were divided into single group and combined group according to the random number table method,with 51 case in each group.The single group was treated with octreotide,and the combined group was treated with ulinastatin based on the treatment of the single group.The clinical efficacy,symptom relief time,levels of serum inflammatory factors including C-reactive protein(CRP),interleukin-6(IL-6),procalcitonin(PCT),hemoglobin(Hb)and albumin(Alb),and incidence of adverse reactions were compared between the two groups.Results The total effective rate of the combined group(96.08%,49/51)was higher than that of the single group(78.43%,40/51),P<0.05.The time of bloating relieving,abdominal pain relieving,recover time of blood amylase,and recover time of eating in the combined group were shorter than those of the single group(all P<0.05).The levels of CRP,IL-6 and PCT in the combined group were lower than those in the single group(all P<0.05),while the levels of Hb and Alb in the combined group were higher than those in the single group(P<0.05).The incidence of adverse reactions in the combined group was 1.96%(1/51),lower than the 15.69%(8/51)in the single group(P<0.05).Conclusions Ulinastatin combined with octreotide in the treatment of pancreatitis can shorten the time of symptom relieving,reduce the body inflammation,improve the levels of Hb and Alb,and improve the clinical efficacy and safety.
作者
郭振凯
谢静
何凤娟
Guo Zhenkai;Xie Jing;He Fengjuan(Department of Gastroenterology,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,China;Department of Diagnostics,Clinical College of Sanquan College,Xinxiang Medical University,Xinxiang 453000,China)
出处
《中国实用医刊》
2022年第24期104-107,共4页
Chinese Journal of Practical Medicine
关键词
胰腺炎
乌司他丁
奥曲肽
Pancreatitis
Ulinastatin
Octreotide
