摘要
目的探讨可溶性致癌抑制因子2(sST2)、超敏肌钙蛋白I(hs-cTnI)和中性粒细胞与淋巴细胞比值(NLR)对急性有机磷农药中毒早期心肌损伤的影响。方法回顾性分析2018年5月至2021年7月安徽省阜阳市肿瘤医院收治的166例急性有机磷农药中毒患者的临床资料,入院3 d内,根据患者是否并发心肌损伤分为心肌损伤组(32例)与非心肌损伤组(134例)。入院时测定所有研究对象sST2、hs-cTnI和NLR水平,采用logistic回归分析影响因素,分析sST2、hs-cTnI、NLR及三者联合急性有机磷农药中毒早期继发心肌损伤的预测价值。结果心肌损伤组中毒至入院时间、服毒量、入院时急性生理与慢性健康评分(APACHEⅡ)、白细胞计数、肌酸激素同工酶(CK-MB)、乳酸脱氢酶、sST2、hs-cTnI、NLR、重度中毒比例占比高于非心肌损伤组,差异有统计学意义(P<0.05)。中毒至入院时间、重度中毒、入院时APACHEⅡ评分、sST2、hs-cTnI、NLR为急性有机磷农药中毒早期继发心肌损伤的影响因素(OR>1,P<0.05)。sST2、hs-cTnI、NLR及三者联合预测急性有机磷农药中毒早期继发心肌损伤的曲线下面积(AUC)值分别为0.718、0.745、0.780、0.853。结论sST2、hs-cTnI、NLR可用于预测急性有机磷农药中毒早期继发心肌损伤,且三者联合的预测价值更高。
Objective To investigate the effects of soluble suppression tumorigenicity 2(sST2),high-sensitivity troponin I(hs-cTnI)and neutrophil-to-lymphocyte ratio(NLR)on early myocardial injury in acute organophosphorus pesticide poisoning.Methods The clinical data of 166 patients with acute organophosphorus pesticide poisoning admitted to Fuyang Cancer Hospital in Anhui Province from May 2018 to July 2021 were retrospectively analyzed,and within 3 d of admission,the patients were divided into myocardial injury group(32 cases)and non-myocardial injury group(134 cases)according to whether they had concomitant myocardial injury.The levels of sST2,hs-cTnI,and NLR were measured on admission for all study subjects,and logistic regression was used to analyze the influencing factors,and the predictive value of sST2,hs-cTnI,NLR,and the combination of the three for early secondary myocardial injury in acute organophosphorus pesticide poisoning.Results The time from poisoning to admission,amount of poison taken,acute physiological,and chronic health score(APACHEⅡ)at admission,white blood cell count,creatine hormone isoenzyme(CK-MB),lactate dehydrogenase,sST2,hs-cTnI,NLR,and proportion of severe poisoning in the myocardial injury group were higher than those in the non-myocardial injury group,and the differences were statistically significant(P<0.05).The area under the curve(AUC)values for sST2,hs-cTnI,NLR,and the combination of the three to predict early secondary myocardial injury in acute organophosphorus pesticide poisoning were 0.718,0.745,0.780,and 0.853,respectively.Conclusion sST2,hs-cTnI,and NLR can be used to predict early secondary myocardial injury in acute organophosphorus pesticide poisoning,and the predictive value of the combination of the three is higher.
作者
管红宝
高勤虎
邹洁
王仲众
GUAN Hongbao;GAO Qinhu;ZOU Jie;WANG Zhongzhong(Department of Emergency Medicine,Fuyang Cancer Hospital,Anhui Province,Fuyang 236000,China)
出处
《中国医药导报》
CAS
2023年第7期101-104,122,共5页
China Medical Herald
基金
安徽省高等学校自然科学研究重点项目(KJ2018A0814)。
关键词
急性有机磷农药中毒
心肌损伤
可溶性致癌抑制因子2
超敏肌钙蛋白Ⅰ
中性粒细胞与淋巴细胞比值
Acute organophosphorus pesticide poisoning
Myocardial injury
Soluble suppression of tumorigenicity 2
High-sensitivity troponin I
Neutrophil to lymphocyte ratio
