摘要
目的分析转化生长因子-β_(1)(TGF-β_(1))联合活化部分凝血活酶时间(aPTT)对急性ST段抬高型心肌梗死(STEMI)患者高血栓负荷(HTB)的预测价值。方法选取140例STEMI患者,视血栓负荷情况分为HTB组66例和低血栓负荷(LTB)组74例,采用酶联免疫吸附法与凝固法检测血清TGF-β_(1)水平与aPTT。通过多因素Logistic回归分析STEMI患者HTB的影响因素,受试者工作特征(ROC)曲线分析血清TGF-β_(1)水平和aPTT对STEMI患者HTB的预测价值。结果HTB组男性、吸烟比例和年龄、白细胞计数、TGF-β_(1)水平高于LTB组,aPTT短于LTB组(P均<0.05)。多因素Logistic回归分析显示,年龄增加(OR=1.033,95%CI:1.005~1.063)、吸烟(OR=1.880,95%CI:1.102~3.208)、TGF-β_(1)升高(OR=1.924,95%CI:1.047~3.536)为STEMI患者HTB的独立危险因素,aPTT延长(OR=0.893,95%CI:0.820~0.972)为独立保护因素(P均<0.05)。ROC曲线分析显示,血清TGF-β_(1)水平和aPTT单独与联合预测STEMI患者HTB的ROC曲线下面积(AUC)分别为0.786、0.711、0.840,灵敏度分别为64.89%、59.54%、83.21%,特异度分别为81.88%、71.81%、70.47%。血清TGF-β_(1)水平和aPTT联合预测STEMI患者HTB的AUC大于二者单独预测(P均<0.05)。结论血清TGF-β_(1)水平升高和aPTT缩短与STEMI患者HTB密切相关,可作为STEMI患者HTB的辅助预测指标,二者联合对STEMI患者HTB的辅助预测价值较高。
Objective To analyze the predictive value of transforming growth factor-β_(1)(TGF-β_(1))combined with activated partial thromboplastin time(aPTT)for high thrombotic burden(HTB)in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods Totally 140 STEMI patients were selected and divided into the HTB group(n=66)and low thrombus burden(LTB)group(n=74)according to thrombus load.TGF-β_(1)and aPTT were measured by enzyme-linked immunosorbent assay with coagulation.The factors influencing HTB in STEMI patients were analyzed by multi-factor Logistic regression,and the predictive value of TGF-β_(1)and aPTT for HTB in STEMI patients was analyzed by receiver operating characteristic(ROC)curves.Results Male,smoking percentage and age,white blood cell count,and TGF-β_(1)were higher in the HTB group than in the LTB group,and aPTT was shorter than that in the LTB group(all P<0.05).Multi-factor Logistic regression analysis showed that increasing age(OR=1.033,95%CI:1.005 to 1.063),smoking(OR=1.880,95%CI:1.102 to 3.208),and elevated TGF-β_(1)(OR=1.924,95%CI:1.047 to 3.536)were independent risk factors for HTB in STEMI patients,and prolonged aPTT(OR=0.893,95%CI:0.820 to 0.972)was an independent protective factor(all P<0.05).ROC curve analysis showed that the area under the curves(AUCs)of serum TGF-β_(1)and aPTT alone and in combination were 0.786,0.711 and 0.840 respectively,with sensitivities of 64.89%,59.54%and 83.21%,and specificities of 81.88%,71.81%and 70.47%,respectively,in predicting HTB in STEMI patients.AUC of TGF-β_(1)and aPTT combined in predicting HTB in STEMI patients was greater than that of either alone(both P<0.05).Conclusion Elevated TGF-β_(1)and shortened aPTT are closely related to HTB in STEMI patients and can be used as auxiliary predictors of HTB in STEMI patients,and the combination of the two has higher auxiliary pre-dictive value for HTB in STEMI patients.
作者
关洁
孙佳莹
蒋丽鑫
邱丽
谢荣盛
GUAN Jie;SUN Jiaying;JIANG Lixin;QIU Li;XEI Rongsheng(Clinical Laboratory,The First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;不详)
出处
《山东医药》
CAS
2023年第10期26-30,共5页
Shandong Medical Journal
基金
黑龙江省卫生健康委科研课题(2020-104)。
