摘要
目的探讨腹膜透析患者腹透引出液中生物标志物的变化及其与腹膜小分子溶质转运速率(PSTR)的关系。方法选取2014年9月29日至2018年4月26日天津中医药大学第一附属医院腹透中心70名新置管腹膜透析患者。测量不同时间点腹透引出液中生物标志物纤溶酶原激活物抑制剂-1(PAI-1)、基质金属蛋白酶-2(MMP-2)和血管内皮生长因子(VEGF)的水平以及随访2年4 h透析液/血肌(D/P)肌酐值,并考察腹透引出液中生物标志物与4 h D/P肌酐的相关性。结果纵向研究显示PAI-1(P<0.001)和VEGF(P=0.04)随腹膜透析持续时间增加而增加。基线时的PSTR和随访2年时的PSTR均与基线时的PAI-1、MMP-2和VEGF水平显著相关。2年时的PSTR也与6个月时的MMP-2水平和基线时的PAI-1水平相关。结论在2年期间腹膜透析患者腹透引出液中的生物标志物PAI-1、MMP-2和VEGF与PSTR呈正相关。
Objective To investigate the changes of biomarkers in peritoneal dialysis patients'peritoneal drainage fluid and their relationship with the peritoneal small molecule solute transport rate(PSTR).Methods Seventy newly-tubed peritoneal dialysis patients from the Peritoneal Dialysis Center of the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine from September 29,2014 to April 26,2018 were selected.The levels of biomarkers plasminogen activator inhibitor-1(PAI-1),matrix metalloproteinase-2(MMP-2)and vascular endothelial growth factor(VEGF)in the peritoneal dialysis priming fluid were measured at different time points and 4 h dialysate/blood muscle(D/P)creatinine values at 2 years of follow-up,and the correlation between biomarkers in the extracted peritoneal fluid and 4 h D/P creatinine was examined.Results Longitudinal studies showed an increase in PAI-1(P<0.001)and VEGF(P=0.04)with increasing duration of peritoneal dialysis.PSTR levels at baseline and after 2 years of follow-up were significantly correlated with PAI-1,MMP-2,and VEGF levels at baseline.PSTR at 2 years was also correlated with MMP-2 levels at 6 months and PAI-1 levels at baseline.Conclusions The biomarkers PAI-1,MMP-2,and VEGF in peritoneal dialysis drainage fluid are positively correlated with PSTR in peritoneal dialysis patients during the 2-year period.
作者
郝娜
徐致远
唐好知
渠雅君
李婉雯
Hao Na;Xu Zhiyuan;Tang Haozhi;Qu Yajun;Li Wanwen(Department of Nephropathy,the First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300381,China;National Clinical Research Center for Chinese Medicine Acupuncture Maxibustion,Tianjin 300381,China)
出处
《国际生物医学工程杂志》
CAS
2022年第4期307-311,共5页
International Journal of Biomedical Engineering
基金
国家自然科学基金青年项目(81904141)
湖北陈孝平科技发展基金(CXPJJH122003-09)
天津市科技计划项目(22KPHDRC00040)。
关键词
新置管
腹膜透析
腹透引出液
纤溶酶原激活物抑制剂-1
基质金属蛋白酶-2
血管内皮生长因子
腹膜转运速率
New peritoneal catheter
Peritoneal dialysis
Fluid derived from peritoneal cavity
Plasminogen activator inhibitor-1
Matrix metalloproteinase-2
Vascular endothelial growth factor
Peritoneal transport rate
