摘要
氧化应激可影响卵母细胞质量和早期胚胎发育,被认为是女性不孕症的病因之一。改善氧化应激对生殖健康至关重要。褪黑素是一种人体自身分泌的抗氧化剂,通过改善线粒体功能和减轻活性氧的损伤而发挥作用。本文从卵巢生理性老化、玻璃化冷冻、未成熟卵母细胞体外成熟相关的氧化应激稳态失衡阐述褪黑素在生殖健康中的应用。
Oxidative stress can affect oocyte quality and early embryonic development,whi ch is considered to be one of the causes of female infertility.Improving oxidative stress is essential for reproductive health.Melatonin is an antioxidant secreted by the body,which can improve mitochondrial function and reduce the damage of reactive oxygen species.This article describes the application of melatonin in reproductive health in terms of the imbalance of oxidative stress homeostasis related to ovarian physiological aging,vitrificati on and freezing,and maturation of immature oocytes in vitro.
作者
孟庆艳
刘双
赵昍朋
李宝山
程东凯
MENG Qingyan;LIU Shuang;ZHAO Xuanpeng;LI Baoshan;CHENG Dongkai(Reproductive Laboratory,Jinghua Hospital of Shenyang,Liaoning Province,Shenyang 110001,China)
出处
《妇儿健康导刊》
2023年第6期23-25,29,共4页
JOURNAL OF WOMEN AND CHILDREN'S HEALTH GUIDE
关键词
褪黑素
卵母细胞质量
辅助生殖
Melatonin
Oocyte quality
Assisted reproduction
