摘要
目的分析产后大出血输血治疗中输入不同配比新鲜冰冻血浆(fresh frozen plasma,FFP)和红细胞(red blood cell,RBC)悬液对凝血功能影响。方法选取2019年7月至2022年7月于绍兴市柯桥区妇幼保健院住院的120例产后大出血患者,根据FFP:RBC悬液输注配比分为对照1组(n=40)、对照2组(n=40)和观察组(n=40),对照1组输注FFP:RBC悬液输注配比为1:2,对照2组输注FFP:RBC悬液输注配比为1:3,观察组输注FFP:RBC悬液输注配比为1:1,比较3组凝血功能指标、血清涎液化糖链抗原-6(krebs von den lungen,KL-6)水平、输血治疗期间输血相关急性肺损伤(transfusion-related acute lung injury,TRALI)发生率、24h内死亡率以及不良反应总发生率。结果输血6h后,观察组纤维蛋白原(fibrinogen,FIB)高于对照1组和对照2组,活化部分凝血活酶时间(activated partial thromboplastin time,APTT)、凝血酶时间(thrombin time,TT)、凝血酶原时间(prothrombin time,PT)均低于对照1组和对照2组,血清KL-6水平高于对照1组和对照2组,差异均有统计学意义(P<0.05)。观察组TRALI发生率、不良反应总发生率均低于对照1组和对照2组,差异均有统计学意义(P<0.05)。观察组24h内死亡率与对照1组、对照2组比较,差异均无统计学意义(P>0.05)。结论产后大出血患者在输血治疗期间,输注比为1:1的FFP:RBC悬液,可有效改善凝血功能,提高血清KL-6水平,降低TRALI发生率与不良反应发生率,有效性、安全性较高。
Objective To analyze the effect of different ratios of fresh frozen plasma(FFP)and red blood cell(RBC)suspension on coagulation function in blood transfusion treatment of postpartum hemorrhage.Methods A total of 120 patients with postpartum haemorrhage hospitalized in Shaoxing Keqiao District Maternal and Child Health Hospital from July 2019 to July 2022 were selected and divided into control group 1(n=40),control group 2(n=40)and observation group(n=40)according to the infusion ratio of FFP:RBC suspension,the infusion ratio of FFP:RBC suspension in control group 1 was 1:2,the infusion ratio of FFP:RBC suspension in control group 2 was 1:3,and the infusion ratio of FFP:RBC suspension in observation group was 1:1.The coagulation parameters,serum salivary liquefied glycoconjugate antigen-6(krebs von den lungen,KL-6)levels,and the incidence of transfusion-related acute lung injury(TRALI)during transfusion therapy,mortality within 24h and the overall incidence of adverse reactions were compared between the three groups.Results After 6 hours of blood transfusion,the fibrinogen(FIB)in the observation group was higher than that in the control 1 and control 2 groups,and the activated partial thromboplastin time(APTT),thrombin time(TT)and prothrombin time(PT)were lower than those of control group 1 and control group 2,and the serum KL-6 level was higher than those of control group 1 and control group 2,the differences were statistically significant(P<0.05).The incidence of TRALI and the overall incidence of adverse reactions in the observation group were lower than those in the control group 1 and control group 2,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the mortality rate within 24h in the observation group compared with the control 1 and control 2 groups(P>0.05).Conclusion Infusion of FFP:RBC suspension at a ratio of 1:1 during blood transfusion therapy in patients with postpartum haemorrhage is effective in improving coagulation function,increasing s
作者
杜东芬
裘轶超
DU Dongfen;QIU Yichao(Department of Blood Preparation and Supply,Shaoxing Central Blood Station,Shaoxing 312000,Zhejiang,China;Department of Womenʼs Health,Shaoxing Keqiao District Maternal and Child Health Hospital,Shaoxing 312000,Zhejiang,China)
出处
《中国现代医生》
2023年第8期59-62,共4页
China Modern Doctor
关键词
产后大出血
新鲜冰冻血浆
红细胞悬液
凝血功能
Postpartum hemorrhage
Fresh frozen plasma
Red blood cell suspension
Coagulation function
