摘要
重症肌无力(MG)是一种由自身抗体介导的神经-肌肉接头(NMJ)信号传递障碍的获得性自身免疫性疾病。自身抗体检测是国内外MG诊治指南推荐的关键辅助诊断指标。MG自身抗体的检测方法包括放射免疫沉淀法、酶联免疫吸附测定法和细胞免疫荧光法等,研究表明这些检测方法的特异度和敏感度存在客观差异,需要结合临床诊断需求来选择不同的检测方法学。为此,中华医学会神经病学分会神经免疫学组基于国内外MG自身抗体诊断指南、检测技术研究进展和充分征求学组专家意见的基础上形成《重症肌无力自身抗体实验室诊断专家共识2022》。本专家共识对MG自身抗体的检测方法学选择给出指导性建议,进一步促进我国MG自身抗体诊断的规范化。
Myasthenia gravis(MG)is a neuromuscular junction transmission disorder mediated by autoantibodies against acetylcholine receptor,muscle-specific kinase and other autoantigens located at the postsynaptic membrane of the neuromuscular junction.Autoantibody detection has been the preferred auxiliary diagnostic indicator recommended by the MG treatment and diagnostic guidelines.The methods of MG autoantibodies detection mainly include radioimmunoprecipitation,enzyme-linked immunosorbent assay and cell-based assay.There are objective differences in the specificity and sensitivity of each method,and it is necessary to select different detection method in combination with the needs of clinical diagnosis.To this end,Chinese Society of Neuroimmunology edits the"Expert consensus on laboratory diagnosis of myasthenia gravis autoantibodies 2022".This guideline is generated based on previous diagnosis guideline,the progress of antibody detection and the comparison result from the MG antibody examination methodologies.And it provides guiding suggestions on methodological selection to further standardize autoantibodies testing of MG.
作者
中华医学会神经病学分会神经免疫学组
施福东
李治国
Chinese Society of Neuroimmunology;Fu-Dong Shi(不详;Department of Neurology,Tianjin Medical University General Hospital,Beijing Tianjin Neuroimmune Center,Tianjin 300052,China)
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2023年第3期251-256,共6页
Chinese Journal of Neurology
关键词
重症肌无力
自身抗体
实验室诊断
共识
Myasthenia gravis
Autoantibodies
Laboratory diagnosis
Consensus
