摘要
阿尔茨海默病(Alzheimer′s disease,AD)是老年人重大致残致死性疾病之一,早期诊断对于延缓阿尔茨海默病发展及其导致的功能损失具有极为重要的意义,是老年人群主动健康成功落地的关键。早诊对于延缓或者推迟AD病程非常关键,将直接服务于“健康老龄化”的战略需求。本文针对当前在AD预警或早期诊断方面相关前言技术进行回顾,通过综述体液标记物、血液标记物、认知标记物和数字标记物检测等早期诊断技术发展历程和前沿文献资料,为准确识别高风险人群、精准实施干预措施提供研究思路,为老年高致残疾病的早期诊断相关研究提供重要参考。
Alzheimer′s disease(AD)is one of the diseases which cause disability and mortality in older adults.Early diagnosis is of great significance for delaying the development of AD and its related function decline,which can help to achieve the aim of healthy aging.This study reviewed current research about the prediction and early diagnosis of AD,which included literature review on the fields of the development and frontiers of early diagnosis technology in humoral markers,blood markers,cognitive markers detection and digital markers.The study provides the conceptual ideas to help identify the high-risk groupsand deliver interventions accurately,and provides important reference for early diagnosis of the disease in older adults.
作者
罗强
罗雅楠
冯娜娜
李清扬
郑晓瑛
LUO Qiang;LUO Ya-nan;FENG Na-na(Institute of Science and Technology for Brain-Inspired Intelligence,Fudan University,Shanghai,200433,China;不详)
出处
《中国公共卫生》
CAS
CSCD
北大核心
2023年第3期394-399,共6页
Chinese Journal of Public Health
基金
国家自然科学基金(81873909)
上海市自然科学基金(20ZR1404900)
国家社会科学基金(ZD21&ZD187,21CRK014)。
关键词
阿尔茨海默病
老年人
早期诊断
Alzheimer′s disease
older adults
early diagnosis
