摘要
目的 探讨阻力呼吸训练器联合噻托溴铵在慢性阻塞性肺疾病(COPD)稳定期患者中的应用效果。方法 选取信阳市中心医院2019年1月至2021年1月收治的96例COPD稳定期患者,采用动态随机化分组法分为观察组和对照组,各48例。患者入院后均接受常规治疗,对照组在此基础上吸入噻托溴铵,观察组在对照组基础上接受阻力呼吸训练器训练,均治疗8周。比较两组患者治疗前、治疗8周时肺功能[第1秒用力呼气容积(FEV1)、用力肺活量(FVC)、FEV1/FVC]、运动耐量[6分钟步行距离(6MWD)、30秒椅子起坐试验(30-STS)、30秒前壁屈曲试验(30-ACT)]及症状程度[COPD自我评估测试(CAT)问卷];治疗结束后随访3个月,比较两组生活质量[圣乔治呼吸问卷(SGRQ)]。结果 治疗前,两组FEV1、FVC水平及FEV1/FVC比较,差异无统计学意义(P>0.05);治疗8周,两组FEV1、FVC水平及FEV1/FVC比值均较治疗前升高,且观察组较对照组高(P<0.05)。治疗前,两组6MWD、30-STS、30-ACT次数比较,差异无统计学意义(P>0.05);治疗8周,两组6MWD较治疗前延长,30-STS、30-ACT次数较治疗前增多,且观察组6MWD较对照组长,30-STS、30-ACT次数较对照组多(P<0.05)。治疗前,两组CAT评分比较,差异无统计学意义(P>0.05);治疗8周,两组CAT评分较治疗前降低,且观察组评分较对照组低(P<0.05)。治疗前,两组呼吸症状、活动受限、疾病影响评分比较,差异无统计学意义(P>0.05);随访3个月,两组呼吸症状、活动受限、疾病影响评分较治疗前降低,且观察组评分较对照组低(P<0.05)。结论 阻力呼吸训练器联合噻托溴铵治疗COPD稳定期患者可进一步改善肺功能,提高患者运动耐量,还可缓解症状,利于改善患者生活质量。
Objective To investigate effect of resistance breathing trainer complicated by tiotropium bromide on the improvement of patients with stable chronic obstructive pulmonary disease(COPD).Methods A total of 96 patients with stable COPD treated in Xinyang Central Hospital from January 2019 to January 2021 were selected. The patients were divided into observation group and control group by dynamic randomization grouping method, with 48 cases in each group. All patients received routine treatment after admission, the control group was treated with tiotropium bromide inhalation on this basis, and the observation group was treated with resistance breathing trainer on the basis of the control group, both groups were treated for 8 weeks. The pulmonary function [forced expiratory volume in first second(FEV1), forced vital capacity(FVC), FEV1/FVC], exercise tolerance [6-minute walking distance(6MWD), 30-second sit-to-stand(30-STS), 30-second arm curl test(30-ACT)] and the degree of symptoms [COPD self-assessment test(CAT) questionnaire] were compared etween two groups before treatment and 8 weeks after treatment. After the end of treatment, they were followed up for 3 months and compared the quality of life [St. George’s respiratory questionnaire(SGRQ)] of both groups.Results Before treatment, compared the levels of FEV1, FVC and FEV1/FVC in both groups, there was no statistical difference(P>0.05). After 8 weeks of treatment, the levels of FEV1, FVC and FEV1/FVC were increased, and the levels of FEV1, FVC and FEV1/FVC in the observation group were higher than those in the control group(P<0.05). Before treatment, compared 6MWD, the times of 30-STS and 30-ACT in both groups, there was no statistical difference(P>0.05). After 8 weeks of treatment, the 6MWD of both groups was prolonged and the times of 30-STS and 30-ACT were more than those before treatment, and the 6MWD in the observation group was longer than that in the control group, and the times of 30-STS and 30-ACT were more than those in the control group(P<0.05). Befo
作者
胡海涛
HU Haitao(Department of Respiratory and Critical Care Medicine,Xinyang Central Hospital,Xinyang 464000,China)
出处
《河南医学研究》
CAS
2023年第4期683-687,共5页
Henan Medical Research
关键词
慢性阻塞性肺疾病
阻力呼吸训练器
噻托溴铵
肺功能
运动耐量
生活质量
chronic obstructive pulmonary disease
resistance breathing trainer
tiotropium bromide
pulmonary function
exercise tolerance
quality of life
