摘要
甲基化转移酶3(METTL3)是N6-甲基腺嘌呤(m6A)最主要的甲基化酶,通过影响甲基化水平、癌症相关基因mRNA稳定性、癌基因表达及癌细胞信号通路等多种调节机制在乳腺癌发生、发展中的发挥作用。文章对METTL3在乳腺癌中的调节机制进行整理和分析,并总结METTL3在乳腺癌发生和发展中的最新研究进展。
Methyltransferase-like 3(METTL3),as the most important methylase of N6-methyladenine(m6A),plays an important role in the development and progression of breast cancer by influencing various regulatory mechanisms,such as methylation level,mRNA stability of cancer-related genes,oncogene expression and cancer cell signaling pathways.This paper reviews the regulatory mechanism of METTL3 in breast cancer and summarizes the latest research progress of METTL3 in the development and progression of breast cancer.
作者
祝嘉
文锦旭
张佳谊
王跃欣
Zhu Jia;Wen Jinxu;Zhang Jiayi;Wang Yuexin(Graduate School,North China University of Science and Technology,Tangshan 060000,China;Graduate School,Hebei Medical University,Shijiazhuang 050001,China;Department of Gland Surgery,Hebei General Hospital,Shijiazhuang 050051,China)
出处
《肿瘤研究与临床》
CAS
2023年第1期66-69,共4页
Cancer Research and Clinic
