摘要
目的观察不同频次耳穴刺络放血结合贴压对寻常型痤疮(AV)患者血清免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、睾酮(T)及胰岛素样生长因子-1(IGF-1)水平的影响。方法将90例AV患者根据随机数余数法分为治疗1组、治疗2组和治疗3组,每组30例。三组均采用耳穴刺络放血结合贴压治疗,治疗1组每周治疗1次,治疗2组每周治疗2次,治疗3组每周治疗3次。治疗4周为1个疗程,共治疗3个疗程。分别于治疗开始前一天及每疗程结束后第一天记录痤疮综合分级系统(GAGS)评分,采集3 mL肘正中静脉血液用于检测血清IgG、IgM、T及IGF-1水平。三疗程结束后,依据GAGS评分计算疗效指数,对治疗有效(疗效指数≥20%)且采样完整患者的血清样本进行分析。结果共60例AV患者的数据进行了最终血清相关因子水平分析。治疗3个疗程后,组内比较显示治疗1组患者血清IgG含量较治疗前显著升高(P<0.01),治疗2组的女性患者血清T含量较治疗前显著降低(P<0.05);三组患者血清IGF-1含量均较治疗前显著降低(P<0.05或P<0.01)。各时期三组患者血清IgG、IgM、T及IGF-1水平差异均无统计学意义(P>0.05)。结论耳穴刺络放血结合贴压治疗可以影响AV患者血清IgG、T及IGF-1水平。每周治疗1次、每周治疗2次或每周治疗3次均可降低患者血清IGF-1水平。每周治疗1次可升高患者血清IgG水平,每周治疗2次能降低女性患者血清T水平。降低血清IGF-1水平可能是耳穴刺络放血结合贴压治疗AV的作用机制之一。
Objective To observe the effects of different frequencies of pricking-bloodletting at auricular points plus auricular point sticking therapy on the levels of the serum immunoglobulin G(IgG),immunoglobulin M(IgM),testosterone(T),and insulin-like growth factor-1(IGF-1)in patients with acne vulgaris(AV).Methods Ninety patients with AV were randomly assigned to treatment group 1,treatment group 2,and treatment group 3 according to the random number remainder grouping method,with 30 cases in each group.All three groups received pricking-bloodletting at auricular points plus auricular point sticking therapy.Treatment group 1 was treated once a week,treatment group 2 was treated twice a week,and treatment group 3 was treated 3 times a week.Four-week treatment was taken as 1 treatment course,and 3 treatment courses were observed.On the day before the start of the study and on the day next to the end of each course,the global acne grading system(GAGS)score was recorded,and 3 mL of blood from the median cubital vein was collected to test the serum levels of IgG,IgM,T,and IGF-1.After 3 courses of treatment,the efficacy index was calculated according to the GAGS score,and the serum indicators in patients with effective treatment(efficacy index≥20%)and complete sampling were analyzed.Results A total of 60 patients were included in the final blood indicator analysis.After 3 courses of treatment,the intra-group comparisons showed that the serum IgG level increased significantly in patients in treatment group 1(P<0.01);the serum T level decreased significantly in the female patients in treatment group 2(P<0.05);the IGF-1 level significantly decreased in the patients in all three groups(P<0.05 or P<0.01).There were no significant differences in the serum levels of IgG,IgM,T,and IGF-1 among the three groups at each time point(P>0.05).Conclusion Pricking-bloodletting at auricular points plus auricular point sticking therapy can affect the levels of serum IgG,T,and IGF-1 in AV patients.The level of the serum IGF-1 can be reduced b
作者
张曼
张明健
佘延芬
高亚玉
陈豪
刘今
范玺胜
刘君
张俊茶
ZHANG Man;ZHANG Mingjian;SHE Yanfen;GAO Yayu;CHEN Hao;LIU Jin;FAN Xisheng;LIU Jun;ZHANG Juncha(Hebei University of Chinese Medicine,Shijiazhuang,050200,China;International Joint Research Center for Dominant Conditions of Acupuncture in Hebei Province,Shijiazhuang,050200,China)
基金
河北省高等教育教学改革研究与实践项目,No.2019GJJG279
河北中医学院科技能力提升项目,No.KTZ2019013
河北省中医药管理局中医药类科技计划,No.2015083.
关键词
耳穴贴压
穴位
耳针
耳穴贴压
王不留行
穴
耳尖
耳穴
耳尖
耳穴
面颊
放血疗法
寻常型痤疮
Auricular Point Sticking
Points,Auricular Acupuncture
Auricular Point Sticking,Semen Vaccariae
Point,Erjian(EX-HN6)
Otopoint,Ear Apex(HX_(6,7i))
Otopoint,Cheek(LO_(5,6i))
Bloodletting Therapy
Acne Vulgaris
