摘要
目的:观察重组人脑利钠肽在慢性肺源性心脏病急性发作的临床效果。方法:回顾性分析2018年11月—2020年11月兰州市第一人民医院收治的慢性肺源性心脏病急性发作75例患者的临床资料,按治疗方法不同分为观察组40例和对照组35例。对照组给予常规治疗,观察组在常规治疗基础上联合重组人脑利钠肽治疗。比较两组心率、呼吸频率、氧分压、二氧化碳分压、血氧饱和度及mMRC呼吸困难量表评分,测定血白介素-6(IL-6)、白介素-8(IL-8)、脑钠肽前体(NT-proBNP)及肿瘤坏死因子-α(TNF-α)水平。结果:两组患者治疗后心率、呼吸频率、二氧化碳分压、mMRC评分均较治疗前降低,氧分压和血氧饱和度均较治疗前升高,且观察组改善情况优于对照组,差异均有统计学意义(P<0.05)。两组治疗后IL-6、IL-8、NT-proBNP及TNF-α均较治疗前降低,且观察组低于对照组,差异有统计学意义(P<0.05)。结论:重组人脑利钠肽治疗在慢性肺源性心脏病急性发作中的应用效果较好,值得临床应用。
Objective To observe the clinical effect of recombinant human brain natriuretic peptide in the treatment of acute attack of chronic pulmonary heart disease.Methods The clinical data of 75 patients with acute attack of chronic pulmonary heart disease admitted to The First People’s Hospital of Lanzhou from November 2018 to November 2020 were analyzed retrospectively.The patients were divided into observation group(40 cases)and control group(35 cases).The control group was given routine treatment,and the observation group was treated with recombinant human brain natriuretic peptide and routine treatment.Heart rate,breathing rate,oxygen pressure,carbon dioxide pressure,Oxygenation and modified Medical Research Council(mMRC)dyspnea score were compared between the two groups,the levels of interleukin-6(IL-6),interleukin-8(IL-8),pro-brain natriuretic peptide(NT-pro-BNP)and tumor necrosis factor factor(TNF-α)in peripheral blood were measured.Results After treatment,heart rate,breathing rate,carbon dioxide pressure and mMRC dyspnea score in both groups were decreased,oxygen pressure and oxygenation were increased.The improvement of the observation group was better than that of the control group(P<0.05).After treatment,IL-6,IL-8,NT-pro-BNP and TNF-αin the two groups were lower than before treatment.The degree of decrease in the observation group was better than that in the control group(P<0.05).Conclusion Recombinant human brain natriuretic peptide treatment is effective and safe in treatment of patients with chronic pulmonary heart disease in acute attack reliable results.
作者
范红燕
闫亚男
王莉
付松泉
FAN Hongyan;YAN Yanan;WANG Li;FU Songquan(Department of Geriatrics,The First People’s Hospital of Lanzhou,Lanzhou,Gansu 730050,China)
出处
《医药前沿》
2022年第36期42-44,共3页
Journal of Frontiers of Medicine
基金
兰州市科技发展计划项目(2017-ZD-9)。
关键词
慢性肺源性心脏病
无创呼吸机
重组人脑利钠肽
疗效观察
Pulmonary heart disease
Non-invasive Breathing Machine
Recombinant human brain natriuretic peptide
Curative effect observation
