三联预康复对非小细胞肺癌一线化疗患者临床疗效和生活质量的影响被引量：6

Clinical efficacy and quality of life of trimodal prerehabilitation combined with first-line chemotherapy for NSCLC patients

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摘要目的:探讨三联预康复在非小细胞肺癌患者一线化疗过程中对临床疗效和患者整体生活质量的影响。方法:选择2019年1月~2021年6月在徐州市中心医院肿瘤中心治疗的86例非小细胞肺癌患者,随机分为观察组和对照组各43例,观察组在一线化疗的同时联合三联预康复治疗,对照组仅给予一线化疗。比较2组患者治疗后的疗效、毒副反应,并应用癌症治疗功能评价系统(FACT)的肺癌FACT-L量表评价生活质量。结果:经2周期治疗后,观察组总有效率较对照组稍高,但2组比较差异无统计学意义。主要毒副反应中血小板下降、白细胞下降、肝肾功能损害、口腔黏膜炎等方面2组无显著差异,但在恶心呕吐的发生率方面观察组明显低于对照组(P<0.05)。观察组治疗后日常活动、情绪状况、活动能力、肺癌附加指标的评分及总分均较治疗前及对照组明显增加(均P<0.05),而对照组仅有日常生活和肺癌附加指标较治疗前增加(P<0.05)。结论:一线化疗治疗晚期非小细胞肺癌同时联合三联预康复治疗,在同等疗效的同时能减轻恶心呕吐不良反应;能明显改善患者日常活动、情绪、活动能力及肺癌附加指标的评分,并有效提高患者的整体生活质量。 Objective:To explore the effect of trimodal prerehabilitation on clinical efficacy and quality of life in patients with non-small cell lung cancer(NSCLC)during the first-line chemotherapy.Methods:A total of 86 patients with NSCLC were selected from Oncology Center of Xuzhou Central Hospital from January 2019 to June 2021,and they were randomly divided into observation group(43 cases)and control group(43 cases).The observation group received first-line chemotherapy combined with trimodal prerehabilitation treatment,and the control group only received first-line chemotherapy.The clinical effect after treatment was compared between two groups,and quality of life was evaluated by FACT-L scale.Results:After two cycles of chemotherapy,the effective rate(CR+PR+SD)in the observation group was 81.4%,slightly higher than 76.7%of the control group,but there was no significant difference.The incidence of nausea and vomiting in the observation group was lower than that in the control group(P<0.05).Using FACT-L scale,the scores of PWB,EWB,FWB and LCS as well as the total score in the observation group were significantly higher than those before treatment(P<0.05),they were also higher than those in the control group after treatment(P<0.05).Conclusion:When trimodal prerehabilitation is combined with first-line chemotherapy to treat NSCLC patients,it reduces adverse reaction of nausea and vomiting without influencing efficacy.It can improve the scores of PWB,EWB,FWB and LCS,enhancing the overall quality of life effectively.