摘要
目的探讨血清总胆红素水平与慢血流患者36个月内冠心病发病的相关性。方法连续入选2017年1月至2018年6月期间,就诊新疆医科大学第一附属医院心脏中心的慢血流患者279例。随访36个月,根据患者在随访期间冠心病发病情况分为冠心病慢血流组(16例)与非冠心病慢血流组(263例),分析总胆红素水平与慢血流患者冠心病发病的相关性。结果冠心病慢血流组与非冠心病慢血流组患者之间性别、年龄、既往史等均无显著统计学差异。冠心病慢血流组血清总胆红素水平较非冠心病慢血流组高[11.68(10.19,15.40)μmol/L比9.80(7.50,12.50)μmol/L,P=0.004]。进一步单因素和多因素Cox回归分析表明,血清总胆红素水平是慢血流患者冠心病发病的危险因素(HR=1.321,95%CI 1.101~1.586,P=0.003)。受试者工作特征曲线表明,血清总胆红素水平预测慢血流患者冠心病发病的曲线下面积为0.714(95%CI 0.605~0.823,P=0.004)。结论血清总胆红素水平与慢血流患者冠心病发病存在相关性,是反映慢血流患者预后的重要指标。
Objective To investigate the correlation between serum total bilirubin level and coronary heart disease within 36 months in patients with slow flow.Methods A total of 279 patients with coronary slow flow in the Heart Center of the First Affiliated Hospital of Xinjiang Medical University from January 2017 to June 2018 were enrolled.The patients were followed up for 36 months.According to the incidence of coronary heart disease during the follow-up period,the patients were divided into the coronary heart disease slow flow group(n=16)and non-coronary heart disease slow flow group(n=263).The correlation between total bilirubin level and coronary heart disease in patients with slow flow was analyzed.Results There was no significant difference in gender,age and history of disease between 2 groups.The level of serum total bilirubin in the coronary heart disease slow flow group was higher than in the non-coronary heart disease slow flow group[11.68(10.19,15.40)μmol/L vs.9.80(7.50,12.50)μmol/L,P=0.004].Further univariate and multivariate Cox proportional hazard regression model showed that serum total bilirubin level was a risk factor for CHD in patients with slow flow(HR=1.321,95%CI 1.101-1.586,P=0.003).Receiver operating characteristic curve showed that the area under the curve of serum total bilirubin level for predicting coronary heart disease in patients with slow flow was 0.714(95%CI 0.605-0.823,P=0.004).Conclusion Serum total bilirubin level is correlated with the incidence of coronary heart disease in patients with slow flow,and it is an important indicator to reflect the prognosis of patients with slow flow.
作者
张雪鹤
刘芬
胡恺轩
赵倩
张冀鑫
李文玲
张桐
杨毅宁
李晓梅
ZHANG Xue-he;LIU Fen;HU Kai-xuan;ZHAO Qian;ZHANG Ji-xin;LI Wen-ling;ZHANG Tong;Yang Yi-ning;LI Xiao-mei(Heart Center,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,China)
出处
《中国心血管病研究》
CAS
2023年第3期240-245,共6页
Chinese Journal of Cardiovascular Research
基金
新疆维吾尔自治区高校科研计划(XJEDU2020I013)
新疆维吾尔自治区研究生科研创新项目(XJ2022G158)。
关键词
冠状动脉慢血流
血清总胆红素
冠心病
发病风险
Coronary slow flow
Serum total bilirubin
Coronary heart disease
Risk of coronary heart disease
