摘要
慢性阻塞性肺疾病是一种常见且多发的呼吸系统疾病,以慢性炎症为主要特征,而中性粒细胞弹性蛋白酶作为一种重要炎性蛋白酶,它能消化、水解细胞外基质和上皮连接结构,损害气道上皮完整性、损伤肺组织,在该病的演变进展过程中具有重要意义。文章对两者的相关性进行综述与探讨,为中性粒细胞弹性蛋白酶抑制剂作为慢性阻塞性肺疾病临床用药提供新视野及一定理论基础。
Chronic obstructive pulmonary disease is a common multiple respiratory disease, which is mainly characterized by chronic inflammation. As an important inflammatory protease, neutrophil elastase can digest and hydrolyze extracellular matrix and epithelial junction structure, damage the integrity of airway epithelium, and damage lung tissue, which is of great significance in the evolution and progress of the disease. This article reviews and discusses the correlation between them, providing a new perspective and a certain theoretical basis for the use of neutrophil elastase inhibitors as clinical drugs for chronic obstructive pulmonary disease.
出处
《大众科技》
2023年第1期123-126,116,共5页
Popular Science & Technology
基金
国家自然科学基金地区科学基金(81760853)
国家宋庆龄基金会(2018MZFT-028)。
