摘要
重复刻板行为是众多神经精神类疾病的特征临床表现,严重影响患者的工作学习与日常交流,给家庭和社会带来巨大的精神和经济负担,其病因复杂,表现形式多样。目前的研究表明小胶质细胞与重复刻板行为的产生关系密切,对小胶质细胞的深入研究已成为探索重复刻板行为发生机制的一个研究热点。近年来研究发现多种神经精神类疾病(如额颞叶痴呆、强迫症、孤独症谱系障碍等)的重复刻板行为表现与小胶质细胞有关,然而对于小胶质细胞参与重复刻板行为确切的机制仍缺乏可靠证据。文章就近年来关于小胶质细胞参与重复刻板行为的相关研究进展做一综述。明确重复刻板行为发生的作用细胞,有望为未来开发治疗与重复刻板行为有关的神经精神类疾病提供新的理论基础和治疗靶点。
Restricted and repetitive behaviors is the characteristic clinical manifestation of many neuropsychiatric diseases,which seriously affects the work,study and daily communication of patients,and brings huge mental and economic burden to the family and society.Its causes are complex and its manifestations are diverse.Current studies have shown that microglia is closely related to the occurrence of restricted and repetitive behaviors,and the in-depth study of microglia has become a research hotspot to explore the mechanism of restricted and repetitive behaviors.In recent years,studies have found that restricted and repetitive behaviors of various neuropsychiatric diseases(such as frontotemporal dementia,obsessive-compulsive disorder,autism spectrum disorder)are related to microglia.However,reliable evidence for the exact mechanism of microglia involved in restricted and repetitive behaviors remains lacking.This article reviews the recent research progress of microglia involved in restricted and repetitive behaviors.It is expected to provide a new theoretical basis and therapeutic targeting cell for the development and treatment of neuropsychiatric diseases related to restricted and repetitive behaviors in the future.
作者
李睿
王一卓
蔚洪恩
Li Rui;Wang Yizhuo;Wei Hongen(Department of Neurology,the Fifth Clinical Medical College of Shanxi Medical University,Shanxi Provincial People's Hospital,Taiyuan 030012,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2023年第2期188-192,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金(81671364)
山西省应用基础研究项目(201801D211010)
山西省"四个一批"科技兴医创新计划项目(2020XM32)。
关键词
小胶质细胞
重复刻板行为
神经精神类疾病
Microglia
Restricted and repetitive behaviors
Neuropsychiatric diseases
