摘要
锌合金由于其适宜的腐蚀速率、良好的力学性能,成为继镁合金与铁合金后的一种新型的可降解生物医用金属材料。近年来,研究者对锌合金的设计、加工制备以及降解机理进行了大量研究,但对其体内外生物相容性的研究尚不充分,仅评估了体外细胞毒性、溶血、凝血,少数材料植入动物体内进行了组织相容性的表征。然而生物相容性涉及细胞、组织、血液、免疫等复杂的局部反应和全身反应,除了材料本身的物理化学性质,还受到材料与机体相互作用的影响。本文分析了可降解医用锌合金的化学成分和物相组成,阐明了对其进行生物学评价的方法,并结合锌合金生物相容性研究现状,阐述未来的研究方向。
Zn and its alloys have recently been used as a new class of biodegradable biomedical metals besides magnesium and iron alloys,owing to their moderate corrosion rate and good mechanical properties.In recent years,researchers have rigorously studied the design,processing,and degradation mechanism of Zn alloys,but their biocompatibility has not been well explored.Past research on the biocompatibility of Zn alloys focused on in vitro cytotoxicity,hemolysis,and coagulation,and only a few materials were implanted into animals for characterizing the histocompatibility.Biocompatibility involves complex local and systemic reactions,such as cells,tissues,blood,and immunity.In addition to the physical and chemical properties of the material,the biocompatibility is also affected by interactions between the material and body.In this paper,the chemical and phase compositions of degradable zinc alloys were analyzed,and the biological evaluation methods were clarified.In view of the recent studies on zinc alloy biocompatibility,future research directions were proposed.
作者
王鲁宁
尹玉霞
石章智
韩倩倩
WANG Luning;YIN Yuxia;SHI Zhangzhi;HAN Qianqian(School of Materials Science and Engineering,University of Science and Technology Beijing,Beijing 100083,China;Beijing Advanced Innovation Center for Materials Genome Engineering,Beijing 100083,China;National Institutes for Food and Drug Control,Beijing 102629,China)
出处
《金属学报》
SCIE
EI
CAS
CSCD
北大核心
2023年第3期319-334,共16页
Acta Metallurgica Sinica
基金
国家自然科学基金项目No.51871020
国家重点研发计划项目No.2016YFC1102500。
关键词
锌合金
生物相容性
细胞毒性
血液相容性
zinc alloy
biocompatibility
cytotoxicity
blood compatibility
