摘要
溃疡性结肠炎是一种影响结直肠的慢性炎症性肠病,其发病率和患病率很高,已演变为全球负担。但溃疡性结肠炎的病因和发病机制尚不明确,现有研究认为肠道微环境失衡对溃疡性结肠炎的发生发展至关重要。肠道微环境主要由肠道微生物群及肠黏膜细胞构成,可通过肠道微生物屏障、化学屏障、机械屏障、免疫屏障4个方面参与机体的生理、病理活动。基于此,溃疡性结肠炎的西医治疗多采用益生菌制剂、5-氨基水杨酸制剂、皮质类固醇激素、免疫抑制剂、生物制剂等药物,但其治疗仍存在一定的局限性,因此寻求新的治疗手段是防治溃疡性结肠炎过程中面临的重要问题。近年来随着对传统中医药领域的不断深入探索,越来越多的研究者发现中医药在防治溃疡性结肠炎方面具有独特的优势。中药复方及中药单体可通过多层次、多通路、多靶点调节肠道微环境进而干预溃疡性结肠炎的发生发展,已逐渐成为溃疡性结肠炎防治研究的热点,引发了广泛的关注。故该文在阐释肠道微环境失衡与溃疡性结肠炎的相关性的基础上,在中医药基础理论的认识指导下,从调节肠道菌群、改善化学屏障、保护机械屏障及抑制免疫炎症反应方面系统总结中医药干预溃疡性结肠炎的作用机制,以期为溃疡性结肠炎的中医药研究提供新的思路。
Ulcerative colitis(UC),a chronic inflammatory bowel disease affecting the colorectum with high morbidity and prevalence,has become a global burden. However,the causes and pathogenesis are still unclear. Available studies have verified that the imbalance of intestinal microenvironment is crucial in the occurrence and development of UC. Intestinal microenvironment is mainly composed of intestinal microbiota and intestinal mucosal cells,which are involved in the physiological and pathological activities of the body through the intestinal microbial barrier,chemical barrier,mechanical barrier,and immune barrier. Thus,probiotic agents,5-aminosalicylic acid preparations,corticosteroids,immunosuppressants,biological preparations and other drugs are commonly used in western medicine for the treatment of UC,which,however,have limitations.Therefore,it is the key task for the prevention and treatment of UC to find new therapies. In recent years,it has been found that traditional Chinese medicine(TCM)has unique advantages in the prevention and treatment of UC. Chinese medicine compounds and Chinese medicine monomers can regulate the intestinal microenvironment through multiple pathways and targets,thereby intervening the occurrence and development of UC. It has gradually become a hot spot in the prevention and treatment of UC and attracted extensive attention. Therefore,this study first discussed the correlation between intestinal microenvironment imbalance and UC and then summarized the mechanisms of TCM against UC from the aspects of regulating intestinal flora,improving chemical barrier,protecting mechanical barrier,and inhibiting immune inflammatory response,in order to provide new ideas for the research on TCM in the treatment of UC.
作者
周琼阁
王凯
席作武
宋青青
刘二浩
ZHOU Qiongge;WANG Kai;XI Zuowu;SONG Qingqing;LIU Erhao(Henan University of Chinese Medicine,Zhengzhou 450046,China;The Second Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450002,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第7期222-229,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
河南中医药学科领军人才项目(豫卫中医函[2021]8号)
河南省中医药科学研究专项(2019JDZX082)。
关键词
肠道微环境
溃疡性结肠炎
中医药
慢性炎症
机制
intestinal microenvironment
ulcerative colitis
traditional Chinese medicine
chronic inflammatory
mechanism
