摘要
目的:探究冠心病合并高血压前期患者冠脉狭窄程度与残余胆固醇及常规血脂指标的关系。方法:回顾性分析2020年10月~2022年1月期间本院收治的126例冠心病合并高血压患者的临床资料。通过调取医院信息系统(Hospital information system,HIS)中病例资料采集患者信息。根据患者动脉狭窄情况,将全体研究对象划分为轻度狭窄组(n=78)、重度狭窄组(n=48)。记录患者冠脉狭窄程度、总胆固醇(Total cholesterol,TC)、甘油三酯(Triglycerides,TG)、高密度脂蛋白(High density lipoprotein,HDL-C)、低密度脂蛋白(Low density lipoprotein,LDL-C)、残余胆固醇(Residual cholesterol,RC)水平,并分析冠心病合并高血压前期患者冠脉狭窄程度同上述指标之间的关联。结果:重度狭窄度患者的TC、TG、LDL-C以及RC水平明显高于轻度狭窄度患者(P<0.05);在轻度狭窄组和重度狭窄组患者中,具有多支病变、TC>6.18 mmol·L^(-1)、TG>1.70 mmol·L^(-1)、LDL-C>3.40 mmol·L^(-1)、HDL-C≤1.55 mmol·L^(-1)、RC>0.80 mmol·L^(-1)组别的患者出现重度狭窄的病例数占比明显偏高(P<0.05),Logistic多因素回归分析结果显示,高水平的RC、LDL-C以及低水平HDL-C是高血压合并心脏病患者发生严重冠脉狭窄的独立危险因素(P<0.05)。结论:冠心病合并高血压前期患者冠脉狭窄程度同RC水平、常规血脂指标具有显著关联;高水平RC、LDL-C、低水平HDL-C是发生严重冠脉狭窄的独立危险因素。
Objective:To explore the relationship between the severity of coronary stenosis and residual cholesterol(RC),routine blood lipid indexes in patients with coronary heart disease and hypertension.Methods:A total of 126 patients with coronary heart disease and hypertension admitted to the hospital were retrospectively analyzed between October 2020 and January 2022.The patient information was collected by retrieving case data from the Hospital Information System(HIS).According to the severity of coronary stenosis,they were divided into mild stenosis group(n=78)and severe stenosis group(n=48).The severity of coronary stenosis,levels of total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and RC were recorded.The correlation between the severity of coronary stenosis and the above indexes was analyzed.Results:The levels of TC,TG,LDL-C and RC in patients with severe stenosis were significantly higher than those with mild stenosis(P<0.05).The differences in multi-vessel disease,levels of TC,TG,LDL-C,HDL-C and RC between the two groups were statistically significant(P<0.05).The results of Logistic multivariate regression analysis showed that high levels of RC and LDL-C,and low level of HDL-C were independent risk factors of severe coronary stenosis in patients with hypertension and coronary heart disease(P<0.05).Conclusion:The degree of coronary stenosis in patients with coronary heart disease and prehypertension is significantly correlated with RC levels and routine blood lipid indicators,high levels of RC,LDL-C,and low levels of HDL-C are independent risk factors for severe coronary stenosis in patients with hypertension and heart disease.
作者
刘文会
Liu Wen-hui(Department of Cardiology,The First Affiliated Hospital of Henan University of Science and Technology,Luoyang 471000,Henan,China)
出处
《四川生理科学杂志》
2023年第3期388-391,共4页
Sichuan Journal of Physiological Sciences
关键词
冠脉狭窄程度
冠心病合并高血压
残余胆固醇
血脂
Severity of coronary stenosis
Coronary heart disease combined with hypertension
Residual cholesterol
Blood lipids
