摘要
硒作为必不可少的微量元素,在抗氧化和维持各种代谢过程中的氧化还原稳态方面起到非常重要的作用。随着纳米技术的发展,硒纳米颗粒(selenium nanoparticles,SeNPs)由于其低毒性、易降解和高药效而成为极具潜力的生物医学药物。由于具有激活凋亡或自噬和调节活性氧产生的能力,SeNPs广泛用于抗癌治疗和病原菌的杀灭或清除。另外,SeNPs具有极好的稳定性和药物的包装能力,而成为一种有效的纳米载体,用于抗癌、抗炎和抗感染治疗。有趣的是,SeNPs在免疫调节方面的重要作用(如巨噬细胞和T效应细胞的活化),为抗癌和抗感染治疗提供了新的纳米-免疫协调治疗策略。该文评述了SeNPs的制备方法、安全性,以及在抗感染和抗癌方面的作用及其机制的最新进展,旨在促进其临床研究及应用。此外,该文还阐述了SeNPs在其它方面的功能,为促进其在科学和临床研究提供帮助。
As an essential trace element,selenium plays a very important role in antioxidation and maintaining redox homeostasis in various metabolic processes.With the development of nanotechnology,selenium nanoparticles(SeNPs)have become potential biomedical drugs because of their low toxicity,degradability and high bioavailability.With the ability to activate apoptosis or autophagy by regulating the production of reactive oxygen species(ROS),SeNPs are widely used in anticancer therapy and pathogens killing/clearance.In addition,with excellent stability and drug encapsulation capacity,SeNPs are serving as a kind of effective nano-carriers for anti-cancer and anti-infection treatments.Interestingly,the important role of SeNPs in immune regulation(such as the activation of macrophages and T effector cells)provides a new possibilities to achieve nano-immune synergetic treatment strategy for anti-cancer and anti-infection therapies.In this paper,we review the latest progress of the preparation methods and safety for SeNPs,followed by the advances of anti-infection,anti-cancer effects and its mechanisms,which would be helpful for promoting the pace of clinical research and application.In addition,we also summarize the functions of SeNPs in other aspects,so as to provide beneficial assistance for facilitating its scientific and clinical research.
作者
石廷玉
何彩林
黄胜
刘绪
王嘉军
SHI Ting-yu;HE Cai-lin;HUANG Sheng;LIU Xu;WANG Jia-jun(Medical School of Hubei Minzu University,Enshi Hubei 445000,China;Hubei Key Laboratory of Biologio Resouces Protection and Utilization of Hubei Minzu University,Enshi Hubei 445000,China;Institute of Selenium Science and Industry of Hubei Minzu University,Enshi Hubei 445000,China;Key Laboratory of Agricultural and Environmental Microbiology/Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,China)
出处
《中国药理学通报》
CAS
CSCD
北大核心
2023年第3期406-413,共8页
Chinese Pharmacological Bulletin
基金
国家自然科学青年基金资助项目(No 81801979)
国家自然科学基金地区基金资助项目(No 32160141)
湖北省自然科学基金青年基金资助项目(No 219CFB358)
生物资源保护与利用湖北省重点实验室资助项目(No PT012209)。
关键词
硒
硒纳米颗粒
抗感染
抗癌
自噬
凋亡
selenium
selenium nanoparticles
anti-infection
anti-cancer
autophagy
apoptosis
