摘要
目的探究血清脂蛋白(a)(lipoprotein,Lp(a))水平对冠状动脉性心脏病(简称冠心病)患者用药物洗脱支架行经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)术后主要心血管不良事件(major cardiovascular adverse events,MACE)的预测效果。方法选取2019年1月-2021年12月济南市中医医院收治的114例冠心病患者作为研究对象,术后随访1年并记录MACE发生情况,根据有无发生MACE将全部患者分为无MACE组和MACE组。比较两组患者人口学指标、基础病史及血脂血糖相关生物学指标,分析各观察指标与药物洗脱支架PCI术后MACE的相关性,采取Logistic回归分析冠心病患者药物洗脱支架PCI术后MACE的危险因素。采用ROC曲线分析危险因素的预测能力。结果MACE组TC和Lp(a)水平显著高于无MACE组(P<0.001)。相关性分析结果显示,TC和血清Lp(a)水平与MACE发生呈正相关性(P<0.05,P<0.001)。以Logistic模型回归分析结果显示,TC和血清Lp(a)是PCI术后MACE发生的独立危险因素(P<0.05,P<0.001)。Lp(a)用于预测PCI术后MACE的ROC曲线分析结果显示,AUC为0.937,95%CI:0.874~0.999,P<0.001,最佳截点值是402.575,敏感度为73.3%,特异度为88.9%。结论血清Lp(a)水平升高可作为冠心病患者药物洗脱支架PCI术后MACE的独立危险因素,且有较高预测价值。
Objective To investigate the prediction power of serum lipoprotein(a)(Lp(a))in major adverse cardiovascular events(MACE)after percutaneous coronary intervention(PCI)with drug-eluting stents of patients with coronary heart disease(CHD).Methods A total of 114 patients with coronary heart disease admitted to our hospital from January 2019 to December 2021 were followed up for 1 year after operation and the occurrence of MACE was recorded.All subjects were divided into non-MACE group and MACE group according to the occurrence of MACE.The demographic indicators,basic medical history,and biological indicators related to blood lipids and blood glucose were compared between the two groups.To analyze the correlation between each observation index and MACE after drug-eluting stent PCI.Logistic regression was used to analyze the risk factors of MACE after drug-eluting stent PCI in patients with coronary heart disease.The ROC curve was used to analyze the predictive ability of risk factors.Results The levels of TC and Lp(a)in MACE group were significantly higher than those in the group without MACE(P<0.01).Correlation analysis showed that TC and serum Lp(a)levels were positively correlated with the occurrence of MACE(P<0.05,P<0.001).Logistic regression analysis showed that TC and serum Lp(a)were independent risk factors for MACE after PCI(P<0.05,P<0.001).The AUC of Lp(a)used to predict the ROC curve of MACE after PCI was 0.937(95%CI:0.874~0.999,P<0.001),and the optimal tangent value was 402.575,with sensitivity 73.3%and specificity 88.9%.Conclusion The elevated serum Lp(a)levels can be used as an independent risk factor for MACE in high patients with coronary heart disease after drug-eluting stent PCI,and have high predictive value.
作者
刘建华
乔敏
LIU Jianhua;QIAO Min(Hospital Infection Department of Jinan Traditional Chinese Medicine Hospital,Jinan Shandong 250012,China;Health Department of Jinan Traditional Chinese Medicine Hospital,Jinan Shandong 250012,China)
出处
《转化医学杂志》
2023年第1期53-55,30,共4页
Translational Medicine Journal
关键词
冠心病
脂蛋白(a)
药物洗脱支架
主要心血管不良事件
Coronary heart disease
Lipoprotein(a)
Drug-eluting stent
Major cardiovascular adverse event
