摘要
生物昼夜节律是机体为适应外界环境变化而产生的一种以约24 h为周期,调节机体大多数生理和代谢活动的细胞内机制,又称昼夜节律。昼夜节律是人体健康的中心调节器。它在神经、心血管等多种器官发育过程中起着非常重要的作用。昼夜节律失调与糖尿病、代谢性疾病及肿瘤发生发展等多种疾病相关。目前越来越多的研究表明,昼夜节律同样会影响睾丸、卵巢、卵泡和生殖母细胞的发育,昼夜节律异常也会导致生殖系统相关疾病的发生。昼夜节律的维持主要受到核心时钟基因的调控。本文概述了核心时钟基因在生殖系统相关组织中的表达动态及对生殖功能的调节。理解时钟基因如何调节生殖功能之间的关系将为新的时钟导向治疗策略的发展提供思路和靶点,有助于进一步提高时钟基因异常所致的生殖系统相关疾病的治疗效果。
Biological circadian rhythm,also known as circadian rhythm,is an intraellular mechanism that regulates most physiological and metabolic activities of the body with a cycle of about 24 hours and is produced by the body to adapt to changes in the external environment.Circadian rhythm is the central regulator of human health.It plays a very important role in the developments of nerve,cardiovascular,and other organs.Circadian rhythm disorders are associated with the developments of diabetes,metabolic diseases,tumor,and many other diseases.At present,more and more studies have shown that circadian rhythm also affects the developments of testis,ovaries,follicles,and germ cells,so abnormal circadian rhythm can also lead to the occurrence of diseases related to the reproductive system.The maintenance of circadian rhythm is mainly regulated by core clock genes.In this paper,the expression dynamics of core clock gene in related tissues of reproductive system and its regulation of reproductive function were summarized.Understanding of the clock genes how to regulate the relationship between reproductive functions will provide idea and targets for the development of the new clock-oriented treatment strategies,and will help to further improve the therapeutic effect of the reproductive system related diseases caused by abnormal clock genes.
作者
杨旭清
鲁聪
刘婷婷
吴江旭
王思雨
王树芳
陈西华
贺斌
徐祥波
王乾兴
YANG Xuqing;LU Cong;LIU Tingting;WU Jiangxu;WANG Siyu;WANG Shufang;CHEN Xihua;HE Bin;XU Xiangbo;WANG Qianxing(Zunyi Medical University,Guizhou Province,563006;National Research Institute for Family Plarning,Beijing;Graduate School Peking Union Medical College,Beijing;Xinxiang Medical College)
出处
《中国计划生育学杂志》
2023年第3期725-731,共7页
Chinese Journal of Family Planning
关键词
生物钟
昼夜节律
时钟基因
生殖系统
Biological clock
Circadian rhythms
Clock gene
Reproduction system
