摘要
目的分析EV71引起的中枢神经系统感染过程中,其感染机制是否与OSA1基因多态性存在关系,为临床预防感染制定相关措施提供参考。方法收集2018年3月至2021年10月在本院就诊的EV71感染者,以及体检健康儿资料,使用SNP scan分析OAS1 rs2660和rs1131454 SNP分型。结果本次研究共收集86名EV71感染患儿纳入至观察组,另外收集60名健康体检患儿纳入至对照组。rs2660、rs1131454的基因型和等位基因分布之间比较,P>0.05。在OAS1 rs2660基因SNP方面,与轻度组进行比较,受累组与之比较存在显著差异(P<0.05),其中受累组AG基因型频率明显更高,OR为2.27,95%CI分布范围为1.07~4.85,受累组GG基因型频率明显更低,OR为0.27,95%CI分布范围为0.08~0.97。而受累组OAS1基因SNP与对照组进行对比无显著差异(P>0.05)。结论OAS1基因rs2660 SNP与CNS参与EV71感染的易感性。携带OAS1的儿童rs2660 AG基因型在EV71感染后存在CNS受累风险性更高。
Objective To analyze whether there is a relationship between EV71 infection mechanism and OSA1 gene polymorphism in the process of central nervous system infection,and to provide reference for developing relevant measures for clinical infection prevention.Methods Data of EV71 patients admitted to our hospital from March 2018 to October 2021 and healthy infants were collected.SNP scan was used to analyze SNP typing of OAS1 rs2660 and rs1131454.Results In this study,a total of 86 children with EV71 infection were included in the observation group,and another 60 healthy children with physical examination were included in the control group.Comparison of genotype and allele distribution of rs2660 and rs1131454,P>0.05.In terms of SNP of OAS1 rs2660 gene,there was a significant difference between the affected group and the mild group(P<0.05).The frequency of AG genotype was significantly higher in the affected group(OR was 2.27,95%-CI was 1.07-4.85),and the frequency of GG genotype was significantly lower in the affected group.OR was 0.27,and 95%CI ranged from 0.08 to 0.97.There was no significant difference in SNP of OAS1 gene between the affected group and the control group(P>0.05).Conclusion rs2660 SNP of OAS1 gene is involved in susceptibility of CNS to EV71 infection.Children with rs2660 AG genotypes carrying OAS1 have a higher risk of CNS involvement after EV71 infection.
作者
郭小凤
田斌斌
王雪芹
GUO Xiao-feng;TIAN Bin-bin;WANG Xue-qin(Department of Neonatology,Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China;Internal Medicine Clinic,Kaifeng Children's Hospital,Kaifeng 475000,Henan Province,China)
出处
《罕少疾病杂志》
2023年第3期13-14,19,共3页
Journal of Rare and Uncommon Diseases
