摘要
目的:探究序贯疗法联合益生菌干预对幽门螺杆菌(Hp)相关性慢性萎缩性胃炎的效果及血清胃蛋白酶原、胃泌素-17的影响。方法:选取2020年1月—2021年10月南安市总医院金淘分院收治的100例Hp相关性慢性萎缩性胃炎患者为研究对象,根据随机数表法将患者分为对照组(序贯疗法)和观察组(序贯疗法联合益生菌干预),各50例。比较两组总有效率、Hp根除率、不良反应发生率及治疗前后血清胃蛋白酶原、胃泌素-17表达水平。结果:观察组总有效率及Hp根除率均高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。两组治疗前血清胃蛋白酶原及胃泌素-17比较,差异均无统计学意义(P>0.05);观察组治疗6周、12周后血清胃蛋白酶原及胃泌素-17均高于对照组,差异均有统计学意义(P<0.05)。结论:序贯疗法联合益生菌干预对Hp相关性慢性萎缩性胃炎的效果较好,且可显著改善血清胃蛋白酶原及胃泌素-17的表达。
Objective: To explore the therapeutic effect of sequential therapy combined with probiotic intervention on helicobacter pylori(Hp)-related chronic atrophic gastritis and its influence on serum pepsinogen and gastrin-17. Method: One hundred patients with Hp-related chronic atrophic gastritis who treated in Jintao Branch of Nan’an General Hospital from January 2020 to October 2021 were selected as the objects and randomly divided into the control group(sequential therapy) and the observation group(sequential therapy combined with probiotic intervention) according to random number table method, 50 cses in each group. The total effective rate, Hp eradication rate, incidence of adverse reactions and the expression levels of serum pepsinogen and gastrin-17 before and after treatment were compared between two groups. Result: The total effective rate and Hp eradication rate in the observation group were significantly higher than those in the control group, the differences were statistically significant(P<0.05). There was no significant difference in the incidence of adverse reactions between two groups(P>0.05). There were no significant differences in serum pepsinogen and gastrin-17between two groups before treatment(P>0.05);the levels of serum pepsinogen and gastrin-17 in the observation group after 6 weeks and 12 weeks of treatment were significantly higher than those in the control group, the differences were statistically significant(P<0.05).Conclusion: Sequential therapy combined with probiotic intervention is effective in the treatment of Hp-related chronic atrophic gastritis,and it can significantly improve the expression of serum pepsinogen and gastrin-17.
作者
林小宝
陈江木
LIN Xiaobao;CHEN Jiangmu(Jintao Branch of Nan’an General Hospital,Nan’an 362314,China;不详)
出处
《中外医学研究》
2023年第7期18-21,共4页
CHINESE AND FOREIGN MEDICAL RESEARCH
