摘要
Nur77(Neuron-derived clone 77)是孤儿核受体家族成员之一,其表达和激活在多种生理及病理刺激下被迅速诱导,具有复杂的生物学功能。近年研究显示,Nur77以组织依赖的方式调控葡萄糖代谢,其过程可能在急性呼吸窘迫综合征(ARDS)的发生发展中发挥作用。了解Nur77如何调控葡萄糖代谢及其如何影响ARDS的发生发展,将有望提供操纵Nur77调控葡萄糖代谢的机会并由此探寻ARDS药物治疗的新靶点。本文将围绕Nur77分子生物学功能及其表达、Nur77对葡萄糖代谢的调控及可能在ARDS中的作用的研究进展进行综述。
Nur77(Neuron-derived clone 77)is a member of the orphan nuclear receptor family,whose expression and activation are rapidly induced by a variety of physiological and pathological stimuli and has complex biological functions.Recent studies have shown that Nur77 regulates glucose metabolism in a tissue-dependent manner,which may play a role in the pathoplysidogy of acute respiratory distress syndrome(ARDS).Understanding how Nur77 regulates glucose metabolism and how it affects the development of ARDS will provide an opportunity to manipulate Nur77 regulation of glucose metabolism and thus explore new targets for drug treatment of ARDS.In this paper,we will review the progress of research on the molecular biological function of Nur77 and its expression,the regulation of glucose metabolism by Nur77 and its possible role in ARDS.
作者
黄玉兰(综述)
严慧玲(综述)
蒋玉洁(审校)
HUANG Yu-lan;YAN Hui-ling;JIANG Yu-Jie(Graduate School,Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA;Department of Pulmonary and Critical Care Medicine,Affiliated Hospital of Youjiang Medical University for Nationalities,Baise 533000,Guangxi,CHINA)
出处
《海南医学》
CAS
2023年第5期732-735,共4页
Hainan Medical Journal
基金
国家自然科学基金(编号:81860021)
广西自然科学基金(编号:2021GXNSFAA325003)。
