摘要
目的探讨生长迟缓儿童生长激素治疗效果与甲状腺素水平的关系。方法选取2017年8月至2021年4月收治的接受生长激素治疗的60例生长迟缓儿童为研究对象,所有儿童治疗前均接受甲状腺素水平检测,分析甲状腺素水平与生长迟缓儿童生长激素治疗效果的关系。结果治疗6个月时,60例生长迟缓儿童中治疗有效49例(81.67%),治疗无效11例(18.33%);无效组游离三碘甲状腺原氨酸(FT_(3))、游离四碘甲状腺原氨酸(FT_(4))、生长激素水平低于有效组,促甲状腺激素(TSH)水平高于有效组,差异有统计学意义(P<0.05);建立Logistic回归分析模型显示,血清FT_(3)、FT_(4)、生长激素水平低、TSH水平高与生长迟缓儿童生长激素治疗效果相关(P<0.05);绘制受试者工作曲线(ROC)曲线显示,血清FT_(3)、FT_(4)、TSH水平预测生长迟缓儿童生长激素治疗效果的曲线下面积(AUC)均>0.7,具有一定预测价值,其中联合检测的预测价值最高。结论甲状腺素水平与生长迟缓儿童生长激素治疗效果密切相关,且可预测生长激素治疗效果。
Objective To explore the relationship between thyroxine level and growth hormone therapy(GHT)-related outcome in children with growth retardation(GR).Methods From August 2017 to April 2021,the GRchildren(n=60)treated with GHT in the hospital were enrolled and received detection of thyroxine level before treatment.The relationship between thyroxine level and GHT-related outcome was analyzed.Results The 6-month effective rate and ineffective rate were 81.67%(49/60)and 18.23(11/60),respectively.The effective group were superior to the ineffective group forfree triiodothyronine(FT_(3)),free tetraiodothyronine(FT_(4)),growth hormone(GH)and thyroid stimulating hormone(TSH)(P<0.05).Logistic regression model analysis showed that FT_(3),FT_(4),GH,TSH was closely related to treatment outcome of GHT(P<0.05).The receiver operating characteristic(ROC)curve indicated that the areas under the curve(AUC)of FT_(3),FT_(4) and TSH forpredicting GHT-related outcome was more than 0.7,respectively;and the predictive value of the three combined was the highest.Conclusion For GRchildren,the thyroxine level is closely related to outcome of GHT,which can predict the outcome of GHT.
作者
王月芬
WANG Yuefen(Department of Pediatrics,Wuhu Second People’s Hospital,Anhui,Wuhu 241001,China)
出处
《河北医药》
CAS
2023年第1期85-88,共4页
Hebei Medical Journal
关键词
生长迟缓
甲状腺素
生长激素
治疗结果
growth retardation
thyroxine
growth hormone
treatment effect
