摘要
医疗照射、职业性暴露、应急照射均可引起放射性皮肤损伤,相关的研究大多集中在放射性皮肤损伤的预防与治疗措施方面,但相关分子尚未完全阐明。研究表明,辐射诱导的细胞早衰在放射性皮肤损伤发生发展中发挥重要作用。本文从放射性皮肤损伤机制及细胞早衰促进放射性皮肤损伤的发生发展,电离辐射诱导的细胞早衰信号通路,及细胞早衰在伤口愈合中的作用3个方面进行综述,探讨辐射诱导的细胞早衰与放射性皮肤损伤的关系。
Radiation skin injury can be induced by medical exposure,occupational exposure,and emergency exposure.Many relevant studies focused on the prevention and treatment of radiation-induced skin injury,but the underlying molecular mechanisms have not been fully clarified.It has been demonstrated that radiation-induced premature cellular senescence is involved in radiation skin injury.To discuss the relationship between radiation-induced premature cellular senescence and radiation-induced skin injury,this paper reviewed the mechanism of radiation-induced skin injury,the promotion of premature cellular senescence and related signal pathways,and the role of premature cellular senescence in wound healing.
作者
陈婕
田梅
高玲
Chen Jie;Tian Mei;Gao Ling(Key Laboratory of Radiological Protection and Nuclear Emergency,China CDC,National Institute for Radiological Protection,Chinese Center for Disease Control and Prevention,Beijing 100088,China)
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2023年第2期149-153,共5页
Chinese Journal of Radiological Medicine and Protection
基金
北京市自然科学基金(7202139,7162137)
国家自然科学基金(31570852)。
关键词
电离辐射
细胞早衰
放射性皮肤损伤
伤口愈合
Ionizing radiation
Premature cellular senescence
Radiation-induced skin injury
Wound healing
