摘要
大量超高剂量率动物实验在不同类型的射线、动物和组织器官中观察到Flash效应,即正常组织损伤减小的同时保持肿瘤控制率与常规剂量率相当。但Flash效应机制还没有得到完全的解释,动物实验和临床转化缺乏理论指导。本文明确Flash效应与离体超高剂量率相关实验的差异,提炼出Flash效应机制的3个关键问题,梳理3类假说:氧耗竭、自由基复合和免疫细胞保护。最后,总结分析Flash效应机制研究的现状和面临的挑战,希望为机制研究提供新思路。
The ultra-high dose rate(UHDR)radiation has less side effect while keep comparable tumor control effect with conventional dose rate(CONV)radiation,which was named Flash effect.Recently,the Flash effect has been reported in many animal experiments with various types of radiations,animal species and body parts.However,the underlying mechanism of Flash has still been unraveled,making difficulties for the clinical application.This review pointed out the differences between the Flash effect and the UHDR effect in vitro and proposed three key scientific questions of Flash effect based on three well-known hypotheses,i.e.,oxygen depletion,peroxyl radical recombination and immune cell protection.Finally,the research progresses and challenges of Flash mechanism study are concluded in order to give a clue for further deep investigation.
作者
周婉仪
胡安康
邱睿
李君利
Zhou Wanyi;Hu Ankang;Qiu Rui;Li Junli(Key Laboratory of Particle&Radiation Imaging,Ministry of Education,Department of Engineering Physics,Tsinghua University,Beijing 100084,China)
出处
《中华放射医学与防护杂志》
CAS
CSCD
北大核心
2023年第2期143-148,共6页
Chinese Journal of Radiological Medicine and Protection
基金
国家自然科学基金(12175114,11875036)
国家重点研发计划(2021YFF0603600)
清华大学自主科研项目(20211080081)。
