摘要
目的 探讨复心合剂联合琥珀酸美托洛尔缓释片治疗冠状动脉肌桥心绞痛患者的临床疗效。方法 选择2020年2月—2022年4月于山东中医药大学附属医院、中国中医科学院广安门医院及首都医科大学附属北京安贞医院心内科就诊的冠状动脉肌桥心绞痛患者92例,根据随机数字表法分为对照组与观察组各46例,对照组给予琥珀酸美托洛尔缓释片治疗,观察组在对照组基础上联合复心合剂治疗,观察2组临床疗效,治疗前后中医证候评分、平板运动心电图指标(运动心绞痛时间、运动ST段下移0.1 mV时间)、西雅图心绞痛量表(SAQ)评分、血管内皮功能[血清内皮素(ET-1)、一氧化氮(NO)、血管内皮功能指数(RHI)]。结果 治疗2个月后观察组总有效率高于对照组(89.13%vs. 76.09%,χ^(2)/P=7.568/0.023);治疗2个月后2组中医证候评分中胸闷或胸痛、气短乏力、心慌失眠、食欲不振等评分均较治疗前降低,且观察组低于对照组(t/P=3.318/0.001、4.511/<0.001、2.209/0.030、2.142/0.035)。治疗2个月后2组运动心绞痛时间、运动ST段下移0.1 mV时间、SAQ评分(躯体活动受限程度、心绞痛稳定状态、心绞痛发作情况、治疗满意程度、疾病认知程度)均较治疗前升高,且观察组高于对照组(t/P=4.715/<0.001、6.736/<0.001、2.844/0.006、2.293/0.024、3.190/0.002、6.084/<0.001、2.229/0.028)。治疗2个月后2组ET-1水平均较治疗前降低,NO水平及RHI指数均较治疗前升高,且观察组优于对照组(t/P=8.213/<0.001、3.073/0.003、2.472/0.015)。结论 复心合剂联合琥珀酸美托洛尔缓释片治疗冠状动脉肌桥心绞痛患者疗效显著。
Objective To investigate the clinical effect of Fuxin Heji Decoction combined with metoprolol succinate sustained release tablets in the treatment of coronary artery myobridge angina. Methods From February 2020 to April 2022, 92 patients with angina pectoris of coronary artery muscle bridge were selected from the Department of Cardiology of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Guang’anmen Hospital of the Chinese Academy of Traditional Chinese Medicine and Beijing Anzhen Hospital of the Capital Medical University. They were divided into the control group and the observation group according to the random number table method, with 46 patients in each group. The control group was treated with metoprolol succinate sustained-release tablets, and the observation group was treated with Fuxin Heji Decoction on the basis of the control group, The clinical effects of the two groups were observed, including the score of TCM syndromes, the index of treadmill exercise electrocardiogram(the time of angina pectoris during exercise, the time of ST segment moving down 0.1 mV), the score of the Seattle Angina Scale(SAQ), the vascular endothelial function serum endothelin(ET-1), nitric oxide(NO), and the vascular endothelial function index(RHI) before and after treatment. Results After 2 months of treatment, the total effective rate of the observation group was significantly higher than that of the control group(89.13% vs 76.09%,χ^(2)/P=7.568/0.023).After 2 months of treatment, the scores of chest tightness or chest pain, shortness of breath, insomnia, and anorexia in the two groups were lower than those before treatment, and the observation group was lower than the control group(t/P=3.318/0.001, 4.511/<0.001, 2.209/0.030, 2.142/0.035). After 2 months of treatment, the time of exercise angina pectoris, the time of movement ST segment downward 0.1 mV, and the SAQ score(the degree of physical activity restriction, the stable state of angina pectoris, the incidence of angina pectoris, the d
作者
张娟
武佶
魏希进
杨士伟
Zhang Juan;Wu Ji;Wei Xijin;Yang Shiwei(Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Shandong Province,Jinan 250000,China;不详)
出处
《疑难病杂志》
CAS
2023年第3期253-257,271,共6页
Chinese Journal of Difficult and Complicated Cases
基金
山东省自然科学基金联合基金重点支持项目(ZR2021LZY038)
山东省自然科学基金面上项目(ZR2021LZY011)
山东省中医药科技发展计划(2021M180)
山东省中医药特色疗法(验方)(3700020699)
山东省老年医学学会2021年科技攻关项目(LKJGG2021W106)
齐鲁流派中医学术流派传承项目(鲁卫函[2022]93号)。
关键词
冠状动脉肌桥
心绞痛
复心合剂
琥珀酸美托洛尔缓释片
临床疗效
Coronary myocardial bridge
Angina
Fuxin Heji Decoction
Metoprolol succinate sustained-release tablets
Clinical effect
