摘要
背景:吞咽是一种复杂的运动,吞咽的整个过程需要2个大脑半球皮质、脑干、特定的脑神经和咽部感受器之间的协同参与,而大脑皮质在吞咽过程中的作用及其对吞咽的影响仍然是一个待解决的问题。目的:使用功能性近红外光谱分析健康成年人反复唾液吞咽测试时大脑皮质的激活及偏侧化情况。方法:纳入27名健康成年人,其中男13名、女14名,年龄(20.41±1.66)岁,在功能性近红外光谱采集过程中进行反复唾液吞咽测试,分析该任务状态下的脑区激活情况,并计算激活脑区的偏侧化分布。结果与结论:①在反复唾液吞咽测试任务时,受试者双侧初级躯体感觉皮质、双侧初级运动皮质、双侧运动前区和辅助运动皮质区、双侧额下回三角部、双侧额极区及双侧背外侧前额叶均明显激活。半数以上受试者在反复唾液吞咽测试任务中存在大脑皮质半球的偏侧化,但大脑半球偏侧化存在较大变异性,且与受试者利手无明显关系。②将健康成年人作为受试者探究吞咽有关的激活区,能更准确地了解吞咽过程中的神经活动,对于进一步探究吞咽功能障碍具有重要意义。
BACKGROUND:Swallowing is a complex movement that requires the synergistic involvement between the cortices,brainstem,specific brain nerves and pharyngeal receptors of the two cerebral hemispheres.The role of the cerebral cortex in the swallowing process and its influence on swallowing remain to be solved.OBJECTIVE:To analyze cortical activation and lateralization during the repetitive saliva swallowing test in healthy adults using functional near-infrared spectroscopy.METHODS:Twenty-seven healthy subjects,aged(20.41±1.66)years,were enrolled,including 13 males and 14 females.All the subjects underwent the repetitive saliva swallowing test during functional near-infrared spectroscopy measure.The brain regions activated by the task were analyzed and the lateralization index of the activated brain regions was calculated.RESULTS AND CONCLUSION:During the repetitive saliva swallowing test,the bilateral primary somatosensory cortex,bilateral primary motor cortex,bilateral pre-motor and supplementary motor cortex,bilateral pars triangularis,bilateral frontopolar area,and bilateral dorsolateral prefrontal cortex were significantly activated.More than half of the subjects had cortical hemispheric lateralization in the repetitive saliva swallowing test,but there was greater variability in hemispheric lateralization and no significant association with subject’s handedness.The use of healthy adults as subjects in this study to explore the activated areas associated with swallowing allows us to more accurately understand the neural activity during swallowing,which is important for further investigation of swallowing dysfunction.
作者
彭昕珂
贾飞阳
刘静
刘红雅
周桂娟
刘丹妮
郁静
周君
Peng Xinke;Jia Feiyang;Liu Jing;Liu Hongya;Zhou Guijuan;Liu Danni;Yu Jing;Zhou Jun(Department of Rehabilitation,The First Affiliated Hospital of Hengyang Medical School,University of South China,Hengyang 421001,Hunan Province,China;Rehabilitation Medicine Center,The First Affiliated Hospital of Hengyang Medical School,University of South China,Hengyang 421001,Hunan Province,China;Rehabilitation Laboratory,The First Affiliated Hospital of Hengyang Medical School,University of South China,Hengyang 421001,Hunan Province,China)
出处
《中国组织工程研究》
CAS
北大核心
2023年第32期5103-5107,共5页
Chinese Journal of Tissue Engineering Research
基金
国家自然科学基金项目(82002400),项目负责人:周桂娟
湖南省自然科学基金项目(2021JJ30617),项目负责人:刘红雅。
关键词
吞咽
反复唾液吞咽测试
功能性近红外光谱成像技术
脑区激活
偏侧化
swallowing
repetitive saliva swallowing test
functional near-infrared spectroscopy
brain area activation
lateralization
