摘要
目的 观察硝普钠微量泵入联合西地兰对急性左心衰伴肺水肿患者心肺功能及血氧饱和度的影响。方法 将我院2019年4月~2021年3月收治的92例急性左心衰伴肺水肿患者依据治疗方案不同分为研究组、对照组,各46例。对照组在常规治疗基础上应用西地兰治疗,研究组在对照组基础上应用硝普钠微量泵入治疗。比较两组治疗效果、心功能[心搏出量(CO)、左心室射血分数(LVEF)、血清B型脑钠肽水平(BNP)、每搏输出量(SV)]、肺功能[最大通气量(MVV)、残气量(RV)/肺总量(TLC)、一秒用力呼气量(FEV1)、氧合指数(P/F)]、舒张压、收缩压、血氧饱和度、心率、心力衰竭缓解情况和肺水肿症状改善情况。结果 研究组总有效率(93.47%)高于对照组(73.91%)(P<0.05);与治疗前相比,治疗后两组LVEF、CO、SV值均显著升高,BNP值显著降低,且研究组各指标改善程度大于对照组(P<0.05);与治疗前相比,治疗后两组MVV、FEV1、P/F水平均明显上升,RV/TLC水平明显降低,且研究组各指标改善程度大于对照组(P<0.05);治疗后,两组收缩压、舒张压、心率较治疗前明显降低,血氧饱和度较治疗前明显升高,且研究组各指标改善程度大于对照组(P<0.05);治疗后,研究组心力衰竭和肺水肿改善时间较对照组短(P<0.05)。结论 微量泵入硝普钠联合西地兰能改善急性左心衰伴肺水肿患者心肺功能、提高血氧饱和度,有利于促进患者病情恢复。
Objective To study the effect of sodium nitroprusside micropump combined with cedilanid on cardiopulmonary function and blood oxygen saturation in patients with acute left heart failure and pulmonary edema.Methods From April 2019 to March 2021,a total of 92 patients with acute left heart failure and pulmonary edema admitted to the hospital were divided into a study group and a control group according to different treatment plans, with 46 cases in each group.The control group was treated with cedilanid on the basis of conventional treatment, and the study group was treated with sodium nitroprusside micro-pumping treatment on the basis of the control group.The treatment effect, cardiac function [stroke volume(CO),left ventricular ejection fraction(LVEF),serum B-type natriuretic peptide(BNP),stroke volume(SV)],pulmonary function [maximum] were compared between the two groups.ventilation volume(MVV),residual capacity(RV)/total lung capacity(TLC),forced expiratory volume in one second(FEV1),oxygenation index(P/F),diastolic blood pressure, systolic blood pressure, blood oxygen saturation, Heart rate, heart failure relief, and improvement in pulmonary edema symptoms.Results The total effective rate in the study group was 93.47%,which was higher than 73.91% in the control group(P<0.05).Compared with the data before treatment, the LVEF,CO and SV values of two groups after treatment were significantly increased, and the BNP value was significantly decreased.The improvement of the indexes was greater than that of the control group(P<0.05);Compared with the level before treatment, the levels of MVV,FEV1 and P/F of two groups were significantly increased, and the level of RV/TLC was significantly decreased, and the improvement of each index of the study group was greater than that of the control group group(P<0.05);The systolic blood pressure, diastolic blood pressure and heart rate in the two groups were significantly lower after treatment than those before treatment, and the blood oxygen saturation was significantly higher
作者
尚丽丽
黄彦兵
王红辉
SHANG Lili;HUANG Yanbing;WANG Honghui(Dengfeng Traditional Chinese Medicine Hospital CCU,Dengfeng 452470,China)
出处
《潍坊医学院学报》
2022年第6期416-419,共4页
Acta Academiae Medicinae Weifang
关键词
左心衰
急性
硝普钠
肺水肿
西地兰
Acute left heart failure
Sodium nitroprusside
Pulmonary edema
Cedilanid
